Talk:Extracellular matrix

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Does this only refer to animal cells and eukaryotes? it is not clear. Brallan 09:31, 16 November 2006 (UTC) this page is blatantly copied from a website, and is in need of an urgent rewrite...Chefette1223 14:39, 26 June 2007 (UTC)[reply]

I think it only applies to animals. It doesn't apply to plants, fungi, or algal protists since their cells are enclosed within a cell wall. It may not apply to non-algal protists, since they seldom form multicellular structures. The article should probably state that this is a characteristic only of animal cells. --EncycloPetey 04:19, 18 August 2007 (UTC)[reply]

ECM and Regeneration

New research into this has allowed regrowth of human body parts. This is a video clip, I could not find an article to refer to. http://news.bbc.co.uk/2/hi/health/7354279.stm —Preceding unsigned comment added by Bnitin (talk • contribs) 05:51, 1 May 2008 (UTC)[reply]

Article itself [1] 82.36.75.12 (talk) 12:41, 1 May 2008 (UTC)[reply]

It should only refer to animal cells, if that has not been changed I will change it. -simmu1992 —Preceding unsigned comment added by Simmu1992 (talk • contribs) 07:25, 4 November 2008 (UTC)[reply]

That research was discredited about 24hours after it was released. — Preceding unsigned comment added by 128.250.5.248 (talk) 23:38, 28 June 2011 (UTC)[reply]

ECM is not specfic to animals

Hyaluronan (HA) is an extracellular molecule and is synthesised and secreted by bacteria (Streptococcus pyogenes, Pasteurella multocida, Streptococcus equisimilis). It is segregated as a virulence factor and is hypothesised to aid the bacteria in evading the immune system. Considering HA binds a vast amount of factors, including proteins, a matrix will invariably be formed. Although this matrix may not have a structural function, it does have a pathogenic function. In short, HA is localised extracellular of bacteria and HA will bind other products to form a matrix, thus extracellular matrices are not limited to animals. Plants also contain interstitial space, and this space will also be an ECM. The ECM is not specific to animals, and essentially refers to the insoluble (and to an extent soluble factors) proteins, carbohydrates, proteogylcans, glycosaminoglycans and chemokines. --128.250.5.247 (talk) 02:44, 24 March 2010 (UTC)Dreadlocked Scientist[reply]

So when secreted by bacteria and other single-celled organisms an ECM is called a biolfilm?Mtiffany71 (talk) 18:59, 23 July 2010 (UTC)[reply]

Removed from the article something which looks like an advertisement.

I removed the below text from the article as it looks like an advertisement. I decided to put it up here as there is some cited material that could be reused if someone wants to rewrite it.

TR Matrix is a ECM bioscaffold: TR BioSurgical has introduced a bioscaffold having a structure that resembles tertiary embryonic connective tissue, which is responsible for its non-immunogenic property and its ability to upregulate a variety of genes involved in tissue repair, as evidenced by gene microarray analysis and lead to a fetal like or regenerative tissue response. Depending on the tissue type, cells that bind to this bioscaffold will have significant, measurable increases in select tissue repair factors, including aggrecan, connective tissue growth factor (CTGF), transforming growth factors (TGF-β1 and TBF-β3), bone morphogenic protein (BMP-2) and other repair factors. These factors are important for cellular ingrowth, extracellular matrix turnover, scarless wound healing, and sustained vasculogenesis.^[1],^[2],^[3],^[4],^[5],^[6],^[7]. —Preceding unsigned comment added by Veryvery20 (talk • contribs) 18:27, 29 October 2010 (UTC)[reply]

References

^ Klann RC, Lloyd WH, Sutton JC and Hill RS (2003). DNA microarray analysis of gene expression changes in human skin fibroblasts treated with E-Matrix, a novel wound healing hydrogel formulation. Presented at, NIDDK/NIAID/NHLIB Workshop, Advanced Topics in Microarray Analysis, Bethesda, MD. 2003 January 22.
^ Klann RC, LloydB, Sutton J and Hill R. Selective induction of TGF Beta 3 as a marker for scarless regenerative healing in the skin. Presented at North Carolina Tissue Engineering Interest Group Meeting, NC Biotechnology Center, RTP, NC. 2003 June 20.
^ Klann, Richard C.,Lloyd, William H., Sutton, Jereme C.,Shih, Mei-Shu, Enterline, Dave S., and Hill, Ronald S. A novel biopolymer matrix induces BMP-2 production and stimulates bone repair in critical size ulnar defects. Presentation, Regenerate 2004, Seattle, WA, 2004 June 9–12.
^ Usala A-L,Dudek R, Lacy S, Olson J, Penland S,Sutton J, Ziats N, and Hill R. Induction of fetal-like wound repair mechanisms in vivo with a novel matrix scaffolding. Diabetes. 2001 50 (Suppl. 2): A488.
^ Lloyd W, Klann R, Sutton J, Hill R. Tissue specific response to a fetal like extracellular matrix: differential in vitro gene expression associated with regenerative wound repair. Presented at North Carolina Tissue Engineering Interest Group Meeting, September 30, 2004, NC Biotechnology Center, RTP, NC.
^ Klann RC. Fetal like tissue scaffolding as a substrate for regenerative tissue repair. East Carolina University Brody School of Medicine, Department of Anatomy and Cell Biology Seminar Series, November 12, 2003.
^ Lloyd W, Lacy S, Sutton J, Usala A and Hill R. A novel hydrogel copolymer reduces scar formation and increases TGF-β3 gene expression. Platform Presentation at the 15th Annual Symposium on Advanced Wound Care, Baltimore, MD. 2002 April 27–30.

Matrix Gla protein (MGP) is a component of ECM

http://www.uniprot.org/uniprot/P08493 Since MGP is part of the structure then vitamin K2 is important for ECM structure.
Encyclopedant (talk) 06:35, 1 December 2014 (UTC)[reply]

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[1] Klann RC, Lloyd WH, Sutton JC and Hill RS (2003). DNA microarray analysis of gene expression changes in human skin fibroblasts treated with E-Matrix, a novel wound healing hydrogel formulation. Presented at, NIDDK/NIAID/NHLIB Workshop, Advanced Topics in Microarray Analysis, Bethesda, MD. 2003 January 22.

[2] Klann RC, LloydB, Sutton J and Hill R. Selective induction of TGF Beta 3 as a marker for scarless regenerative healing in the skin. Presented at North Carolina Tissue Engineering Interest Group Meeting, NC Biotechnology Center, RTP, NC. 2003 June 20.

[3] Klann, Richard C.,Lloyd, William H., Sutton, Jereme C.,Shih, Mei-Shu, Enterline, Dave S., and Hill, Ronald S. A novel biopolymer matrix induces BMP-2 production and stimulates bone repair in critical size ulnar defects. Presentation, Regenerate 2004, Seattle, WA, 2004 June 9–12.

[4] Usala A-L,Dudek R, Lacy S, Olson J, Penland S,Sutton J, Ziats N, and Hill R. Induction of fetal-like wound repair mechanisms in vivo with a novel matrix scaffolding. Diabetes. 2001 50 (Suppl. 2): A488.

[5] Lloyd W, Klann R, Sutton J, Hill R. Tissue specific response to a fetal like extracellular matrix: differential in vitro gene expression associated with regenerative wound repair. Presented at North Carolina Tissue Engineering Interest Group Meeting, September 30, 2004, NC Biotechnology Center, RTP, NC.

[6] Klann RC. Fetal like tissue scaffolding as a substrate for regenerative tissue repair. East Carolina University Brody School of Medicine, Department of Anatomy and Cell Biology Seminar Series, November 12, 2003.

[7] Lloyd W, Lacy S, Sutton J, Usala A and Hill R. A novel hydrogel copolymer reduces scar formation and increases TGF-β3 gene expression. Platform Presentation at the 15th Annual Symposium on Advanced Wound Care, Baltimore, MD. 2002 April 27–30.

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