Talk:Estriol

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Untitled

The limited research I have done indicates that the estriol is primarily produced by the placenta rather than the fetus. WebMD reference [1]

References

This article needs some type of reference, added tag. --FloNight 20:39, 22 November 2005 (UTC)[reply]

FDA headsup

The MS study needs verifying, particularly since the FDA has started to crack down on estriol prescriptions, and it's become a point of contention. —Preceding unsigned comment added by 143.231.249.141 (talk) 19:42, 7 July 2008 (UTC)[reply]

"[S]everal studies have demonstrated an inverse relationship between estriol levels and breast cancer as well as antitumor effects of estriol.27,111-113 ..." PMID 17217322

Deborah Moskowitz, ND

A Comprehensive Review of the Safety and Efficacy of Bioidentical Hormones for the Management of Menopause and Related Health Risks

Bioidentical Hormones Review

PMID 17217322

Free full text http://www.altmedrev.com/publications/11/3/208.pdf

"...It is well understood that, due to proliferative effect on normal breast cells as well as on numerous breast cancer cell lines, estrogens are contraindicated for women at risk for breast cancer, because, as referenced above, increased estrone and estradiol levels are associated with an increased risk of breast cancer. The supplementation of either of these forms of estrogen increases serum estradiol and estrone due to the pathways by which they are metabolized. In contrast, several studies have demonstrated an inverse relationship between estriol levels and breast cancer as well as antitumor effects of estriol.27,111-113 ... "

...

27. Follingstad AH. Estriol, the forgotten estrogen? JAMA 1978;239:29-30.

...

111. Lemon HM, Wotiz HH, Parsons L, Mozden PJ. Reduced estriol excretion in patients with breast cancer prior to endocrine therapy. JAMA 1966;196:1128-1136.

112. Lemon HM. Pathophysiologic considerations in the treatment of menopausal patients with oestrogens; the role of oestriol in the prevention of mammary carcinoma. Acta Endocrinol Suppl (Copenh) 1980;233:17-27.

113. Lemon HM. Estriol prevention of mammary carcinoma induced by 7,12- dimethylbenzanthracene and procarbazine. Cancer Res 1975;35:1341-1353.

[emphasis added] — Preceding unsigned comment added by 99.190.133.143 (talk) 00:22, 5 February 2012 (UTC)[reply]