Talk:Eplerenone

Contraindicate

The Oxford Dictionary defines contraindicate as "to give indications contrary to; said exp. of symptoms in a diasese which make against the usal treatment, or a particular remedy." The verb's earliest documentation was in 1666 in the present participle form. The earliest recorded usage in the indicative form was in 1767 ("The bark, if nothing contraindicates its use, may prove to be very beneficial.") Another example of the indicative form is "their shape and position contraindicate the possibility of any individual movement of their jaw-angles". The verb is usually used in present or past participle forms and I have never seen it used with a subject of the kind "The manufacturer of eplerenone".--Mirrordor 21:34, 21 November 2010 (UTC) —Preceding unsigned comment added by Mirrordor (talk • contribs)

Caution ...

Looks like this brief write-up needs a reference to avoiding the consumption of grapefruit. — Preceding unsigned comment added by 24.85.242.68 (talk) 18:37, 15 July 2011 (UTC)

In heart failure

Eplerenone is often used where side-effects from spironolactone are a major problem. This is not borne out by a systematic review: doi:10.1016/j.amjmed.2011.12.018 JFW | T@lk 08:59, 30 July 2012 (UTC)

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STUDENT REVIEW

Hi my name is Zack Karmin, and with my partner Claire Hillman, we are editing the page for Eplerenone in order to keep the page up to date and ensure that there is as much drug information as possible. In doing so we have compiled research information on the history of the drug's development, medical uses, pharmacology and adverse effects, along with a table and figure of Eplerenone's chemical structure. We will be sure not to delete any previously posted information, and only add new content. Here is a brief example of the information we plan to add. Thank you:

Medical uses[edit source | edit] Heart Failure[edit source | edit] A variant of the spirolactone group, Eplerenone was developed to contradict the depletion of essential potassium and magnesium levels that are common amongst other mineralocorticoid receptor antagonists[4]. It is a more expensive alternative to spironolactone.[5] The recommended dosage for Eplerenone treating heart failure is 25-50 mg/day, depending on the tolerance of the patient[6]. According to a study comparing both aldosterone blocking agents, the efficacy of Eplerenone over Spironolactone is dependent upon each individual patient[7].

Hypertension[edit source | edit] Eplerenone can be used individually or in combination with other medications to treat hypertension in patients[8]. Dosage ranges from a once daily dose of 50 mg to twice daily 50 mg dosage (no more than 100 mg/day is recommended, as there is no benefit on blood pressure relief)[9]. In an 8 week trial with 417 patients with mild to moderate hypertension, Eplerenone significantly decreased systolic and diastolic blood pressure in a dose-dependent man over a dose range of 50, 100 and 400 milligrams per dose [10]. Eplerenone effectively reduces blood pressure compared to agents such as spironolactone, enalapril, losartan and amlodipine, but it's effect on mortality is still generally unknown [11].

Introduction - Approvals

"Eplerenone is currently approved for sale in the US, ..." How old is this information? I can attest that Eplerenone has been available in Canada for at least 5 years. I'm sure there must be other countries too. In the absence of current information, we shouldn't offer outdated info.Doc.Ian (talk) 06:37, 28 February 2017 (UTC)

I have been prescribed Eplerenone for several years in Australia where it is approved by the Therapeutic Goods Administration. JaimeyTeresa (talk) 10:34, 21 November 2023 (UTC)