Talk:Early-onset Alzheimer's disease

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 7 September 2021 and 8 December 2021. Further details are available on the course page. Student editor(s): Joan1087, Bharatss-SB, Joyjxu1.

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there are 2 books on the disease but I do not know the other one

please put Hannah's heir's into the correct format —Preceding unsigned comment added by 74.10.198.135 (talk) 21:23, 5 December 2010 (UTC)[reply]

Early discussion on Familial Alzheimer disease

See Talk:Familial Alzheimer disease (the article now redirects here). --Matt Lewis (talk) 19:00, 20 August 2008 (UTC)[reply]

Main Alzheimer's article

When this is improved with refs etc, it needs to be linked-to from the main Alzheimer's introduction, in place of the pipe linked "Familial Alzheimer's disease" article, which is only half the story with early-onset AD. --Matt Lewis (talk) 01:22, 19 August 2008 (UTC)[reply]

Quote from article: "employees must discuss their future with their employers and the loss of skills they expect to face" ...This is advocacy journalism at the least. Wikipedia is not in the business of dispensing employment advice, much less in the imperative. 108.4.66.224 (talk) 04:05, 6 May 2012 (UTC)[reply]

Merge Familial Alzheimer's disease into here?

On creating this article, it has occurred to me that Familial Alzheimer's disease may be better placed in here? Does it need it's own article? --Matt Lewis (talk) 01:22, 19 August 2008 (UTC)[reply]

I've been bold and done it. If reverting, please just delete all that is below the Introduction, as I made other edits to the intro at the same time. I'll put a merge up at FAD, which can lead to a 'redirect' being placed there, or a deletion of the duplicated text in here. We can copy the FAD talk page into here (it's only 3 sections long).

What do people think? It can easily be reversed.--Matt Lewis (talk) 01:52, 19 August 2008 (UTC)[reply]

I'm making FAD a redirect, and linking the main AD article to here, to encourage comment/development. --Matt Lewis (talk) 19:00, 20 August 2008 (UTC)[reply]

"Approximately half the cases of early-onset Alzheimer's are Familial Alzheimer's disease"

Source? —Preceding unsigned comment added by 85.179.22.219 (talk) 09:27, 27 February 2011 (UTC)[reply]

Down Syndrome

Just a passing curiosity, but my understanding is that bpeople with Down Syndrome tend to develop Alzheimer's at an early age. If this is true, it might be worth mentioning — Preceding unsigned comment added by 137.43.182.167 (talk) 15:56, 23 October 2011 (UTC)[reply]

Age of 15 needs a citation

A paragraph says "can be as early as 15". There is no citation in this paragraph to indicate this age can start Alzheimer's. Someone needs to add a source to prove it. Stopde (talk) 08:29, 8 December 2012 (UTC)[reply]

Why don't you do it yourself? You can't just order people around while you sit there and do absolutely nothing. United States Man (talk) 16:21, 8 December 2012 (UTC)[reply]

You, have nothing better to do than to be argumentative. I read other wikipedia pages, and I make changes were necessary, and I actually have things I do away from the computer, I realize this is a foreign concept for you, but you really need to take your holier than thou rotten attitude and get a life. Stopde (talk) 08:32, 12 December 2012 (UTC)[reply]

Prognosis

Isn't it the case that early onset AD usually strikes much more slowly than AD in elderly people? I know of cases in which it took several years before a middle aged man's strange behaviour was identified as AD. Many old people die within the same time after the first signs have shown up. Steinbach (talk) 21:59, 1 January 2013 (UTC)[reply]

Life and Death in Assisted Living

Frontline (U.S. TV series) will be running Life and Death in Assisted Living on Tuesday July 30th: http://www.pbs.org/wgbh/pages/frontline/pressroom/frontline-propublica-investigate-assisted-living-in-america/ Please contribute to discussion Talk:Assisted_living#Life_and_Death_in_Assisted_Living XOttawahitech (talk) 03:44, 30 July 2013 (UTC)[reply]

Proposed merge

I have proposed a merge with Swedish mutation because it refers to an unspecified causal of Early-onset Alzheimer's disease, which is thoroughly covered here. LT90001 (talk) 10:25, 28 August 2013 (UTC)[reply]

Possible contradiction

In the summary paragraph at the top, the familial variant is cited as accounting for 13% of all early-onset AD cases but then in the section on Familial Alzheimer's disease it is claimed to account for "approximately half the cases of early-onset Alzheimer's disease." The first has a citation and the figure is indeed found within it, while the latter has no citation. However, I do not know anything about the subject so I leave to the edit, if necessary, to someone who does.

Citation for prevalence

In the first paragraph, 2015-12-19: "It is an uncommon form of Alzheimer's, accounting for only 5-10% of all Alzheimer's cases." However, this is not cited, and this paper ( https://scholar.google.co.uk/scholar?cluster=8371920655832036443&hl=en&as_sdt=0,5 "Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers", Reitz 2014) says 1-5% of all cases, with >95% sporadic. Believe this might be a confusion with familial AD, which is 5-10% of cases but not exactly the same as EOAD.^[1] taliswolf (talk) 12:09, 19 December 2015 (UTC)[reply]

References

^ https://books.google.co.uk/books?id=a221hX4WuwUC&dq=+CLINICAL+DIAGNOSIS+AND+MANAGEMENT+OF+ALZHEIMER%E2%80%99S+DISEASE&lr=&source=gbs_navlinks_s

Terminological confusion

"Early-onset Alz." sometimes means (1) sporadic Alz. when it strikes early (and sporadic Alz. is also known, confusingly, as "late-onset Alz.", leading to expressions such as "an early onset of late-onset Alz."), and sometimes means (2) familial Alz., which most researchers regard as a different disease, but which, either way, is caused by deterministic genes, unlike sporadic Alz.

The authors of this article seem unaware of the above terminological niceties.

I don't know how to fix the article without a sig. rewrite.

Samuel Webster (talk) 15:33, 24 December 2016 (UTC)[reply]

This is still the case seven years later and this article urgently needs to be rewritten, but I feel uncomfortable doing a wholesale re-write without consensus. 'Early-Onset Alzheimer's Disease' simply refers to AD which starts before the age of 65, and this article should probably be limited to that definition, perhaps with statistics regarding prevalence of EOAD, and a brief description of the difference between sporadic and familial disease.

It is true that most EOAD has familial element, but there is some disagreement as to what Familial Alzheimer's disease actually refers to. Autosomal-dominant Alzheimer's disease (ADAD) means dominantly inherited AD, and this article seems to largely be referring to this. I think most of this article should be moved to an article specifically about ADAD. Other terms, such as familial AD (FAD) may encompass ADAD, but may also include AD from non-dominant causes such as the APOE4 allele, so I'm also open to an article called Familial Alzheimer's Disease, which includes sections on the three genes associated with ADAD and also the APOE risk alleles - in fact this would be my preference as a simple solution to begin with. I'm happy to make a start on that article, but fear it would just get merged into this article again! Twrist (talk) 08:37, 15 September 2023 (UTC)[reply]

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"It accounts for around half the cases of early-onset Alzheimer's disease"

This is quite a bold claim and likely overstated. Definitely needs a citation or should be taken out. — Preceding unsigned comment added by 188.154.60.154 (talk) 22:16, 2 June 2019 (UTC)[reply]

Irrelevant paper cited twice

A paper on the role of a specific miRNA is cited twice in this article. Once in a section on the role of the gene PSEN2, and once in the middle of a paragraph on APP.

Neither PSEN2 nor APP is mentioned in the cited article, and the sentences added do not logically flow in their locations. They seem to have been inserted at random.

The article has no relevance for *early onset* AD. Additionally, the article is very recent (2022), and has a very low number of citations. It has not been replicated in the literature, nor is it an especially relevant article in the Alzheimer’s field.

These citations should be removed.

DOI of the article cited: https://doi.org/10.17305/bjbms.2021.6723

Link to anonymous user who made the edits: https://en.m.wikipedia.org/wiki/Special:Contributions/2A02:27B0:4402:5B40:8545:2A14:48B4:12DD

2601:647:CF80:4550:41E6:10F0:9F8C:D17 (talk) 02:16, 23 October 2024 (UTC)[reply]

[1] ttps://books.google.co.uk/books?id=a221hX4WuwUC&dq=+CLINICAL+DIAGNOSIS+AND+MANAGEMENT+OF+ALZHEIMER%E2%80%99S+DISEASE&lr=&source=gbs_navlinks_s

[1]