Talk:Dyskeratosis congenita

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Medicine: Dermatology / Hematology-oncology Low‑importance

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Dyskeratosis congenita.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

The Wikimedia Foundation's Terms of Use require that editors disclose their "employer, client, and affiliation" with respect to any paid contribution; see WP:PAID. For advice about reviewing paid contributions, see WP:COIRESPONSE.

JLRD309 (talk · contribs) has been paid by RepeatDiagnostics.

Readability

PLEASE FOR THE LOVE OF GOD CLEAN UP THIS PAGE!! This looks like a really interesting syndrome/condition. However, I have to use the dictionary a lot to understand it. Readability is important! Too much technical jargon-- please clean up. MiniOreo (talk) 14:00, 12 May 2008 (UTC)[reply]

Not premature aging

"premature aging effect" is scientifically incorrect terminology, giving the mistaken impression that this condition is accelerated aging. I reverted to language used in my edit: "rare progressive congenital disorder which results in what in some ways resembles premature aging (similar to progeria)" --Xris0 (talk) 20:42, 30 January 2010 (UTC)[reply]

Okee-dokey :-) Rcej (Robert) - talk 05:19, 31 January 2010 (UTC)[reply]

Lacking citations

The CHARACTERISTICS section offers a lot of specific information on the symptoms of the disease, however none of it is cited. Cheesefromwater (talk) 14:34, 6 January 2015 (UTC)[reply]

Proposed updates to existing section ‘4. Diagnosis’

This edit request by an editor with a conflict of interest has now been answered.

Please update content to: Since the disease has a wide variety of symptoms, due to the involvement of multiple body systems, diagnostic testing depends on the clinical findings in each individual patient. Commonly used tests include: complete blood count (CBC), bone marrow examination, leukocyte telomere length test (e.g. Flow FISH [1]), pulmonary function test, genetic testing and checking for von Willebrand factor (VMF [2]) level in the blood.

Explanation of issue: Bad grammar; formatting issues; two clinically utilized methods of Dyskeratosis Congenita diagnosis currently not mentioned

References supporting change:

Alter BP, Baerlocher GM, Savage SA, et al. Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood. 2007;110(5):1439-1447. doi:10.1182/blood-2007-02-075598. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1975834/

Savage, S. & Cook, E. Dyskeratosis Congenita and Telomere Biology Disorders: Diagnosis and Management Guidelines. (First ed.) 2015. Accessed at: https://teamtelomere.org/wp-content/uploads/2018/07/DC-TBD-Diagnosis-And-Management-Guidelines.pdf

JLRD309 (talk) 21:00, 18 August 2020 (UTC)[reply]

Hi @JLRD309:, I do not have medical expertise nor experience editing medical articles, so I decided to post a notice to WP:WikiProject Medicine. Hopefully someone there will respond soon. I have also moved your connected contributor banner to the top of the page. Z1720 (talk) 16:35, 27 November 2020 (UTC)[reply]

Thanks for posting the note at WT:MED, Z1720.

JLRD309, we have some (occasionally over-picky) rules about sources for Wikipedia:Biomedical information, and these don't seem to be "the ideal". I was wondering how you felt about https://www.ncbi.nlm.nih.gov/books/NBK22301/#dkc.Diagnosis

Also, I haven't found any other sources that mention VMF, and I wonder whether that is still done or perhaps not a key step in the diagnosis. WhatamIdoing (talk) 20:53, 27 November 2020 (UTC)[reply]

Hi @JLRD309:, I want to make sure you got the note from WhatamIdoing. If you wish to respond please post it below. If there's no response for a couple days I will close the ticket. Thanks. Z1720 (talk) 03:12, 4 December 2020 (UTC)[reply]

Since there has not been a response to WhatamIdoing by the original requester, I am going to close this ticket. If you would like to request these changes again please follow the instructions at Template:Request edit/Instructions. Happy editing! Z1720 (talk) 18:06, 6 December 2020 (UTC)[reply]

Changes to section 4. Diagnosis

The Wikimedia Foundation's Terms of Use require that editors disclose their "employer, client, and affiliation" with respect to any paid contribution; see WP:PAID. For advice about reviewing paid contributions, see WP:COIRESPONSE.

JLRD309 (talk · contribs) has been paid by RepeatDiagnostics.

This edit request by an editor with a conflict of interest has now been answered.

Content to be updated to: Since the disease has a wide variety of symptoms, due to the involvement of multiple body systems, diagnostic testing depends on the clinical findings in each individual patient. Commonly used tests include: complete blood count (CBC), bone marrow examination, leukocyte telomere length test (e.g. Flow FISH [3]), pulmonary function test and genetic testing.
Explanation of issue: Bad grammar; formatting issues; two clinically utilized methods of Dyskeratosis Congenita diagnosis currently not mentioned; no references to support link between von Willibrand factor and diagnosis of dyskeratosis congenita
References supporting change:

Savage SA. Dyskeratosis Congenita. 2009 Nov 12 [Updated 2019 Nov 21]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020. https://www.ncbi.nlm.nih.gov/books/NBK22301/#dkc.Diagnosis
Fernández García, M Soledad, and Julie Teruya-Feldstein. “The diagnosis and treatment of dyskeratosis congenita: a review.” Journal of blood medicine vol. 5 157-67. 21 Aug. 2014. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145822/#__sec12title

@WhatamIdoing: Thanks for your guidance on referencing and for flagging lack of reference for von Willibrand factor, I have no knowledge of a link between this and dyskeratosis congenita diagnosis, I have therefore suggested it is removed.

JLRD309 (talk) 23:45, 8 December 2020 (UTC)[reply]

Thank you for this, JLRD309. I apologize for taking so long to get back to you. By the way, some of us who are interested in medical content hang out at Wikipedia talk:WikiProject Medicine. You are welcome to put the page on your watchlist and join the discussions. We always need people who know things. ;-D WhatamIdoing (talk) 22:07, 27 December 2020 (UTC)[reply]