Talk:Diabetes type 1.5

This is a talk page for a redirect, formerly a disambiguation page. --Bejnar (talk) 21:38, 15 October 2012 (UTC)

Primary topic

Latent autoimmune diabetes is definitely the primary topic. See the literature there cited. There is no mention in the Diabetes mellitus type 2 article of a special type of diabetes mellitus type 2 called Ketosis-prone. There is no mention, and more importantly no citation, in that article that indicates that type 1.5 is used for type 2.0. There is discussion in the Latent autoimmune diabetes article that 1.5 is often diagnosed initially as the more common type 2, but nothing to indicate that Diabetes type 1.5 refers to Diabetes type 2. As there is a primary topic, there is no need for a disambiguation page. Diabetes type 1.5 should redirect to Latent autoimmune diabetes and there is a hatnote there for Ketosis-prone diabetes, if someone wants to write the article. --Bejnar (talk) 19:04, 15 October 2012 (UTC)

Ketosis-prone diabetes

As to Ketosis-prone diabetes (KPD). Doctors Balasubramanyam et al. said: Ketosis-prone diabetes (KPD) is a widespread, emerging, heterogeneous syndrome characterized by patients who present with diabetic ketoacidosis or unprovoked ketosis but do not necessarily have the typical phenotype of autoimmune type 1 diabetes. Multiple, severe forms of beta-cell dysfunction appear to underlie the pathophysiology of KPD. Until recently, the syndrome has lacked an accurate, clinically relevant and etiologically useful classification scheme. Balasubramanyam, A.; Nalini, R.; Hampe, C. S. and Maldonado, M. (2008). "Syndromes of ketosis-prone diabetes mellitus". Endocronology Review. 29 (3): 292–302. doi:10.1210/er.2007-0026.{{cite journal}}: CS1 maint: multiple names: authors list (link) They go on to say: Recent data from longitudinally followed cohorts have clarified the clinical features and taxonomy of some of these syndromes that are “intermediate” between type 1 and type 2 diabetes. However, in Section VI "Pathophysiology of KPD Syndromes", they make it clear that KPD is not type 1.5: here is clearly a spectrum of clinical phenotypes among patients with islet autoantibodies who do not present with ketosis, including those termed “latent autoimmune diabetes in adults” (LADA) (30), “type 1.5 diabetes” (31,32,33), and “slowly progressing type 1 diabetes” (34). A similar spectrum exists in KPD that includes the very different phenotypes of A+β− and A+β+ KPD. A+β− KPD is synonymous with classic, early onset autoimmune type 1 diabetes; A+β+ KPD may overlap with LADA. However, there are differences between LADA, as recently defined by the Immunology of Diabetes Society, and A+β+ KPD patients; most importantly, the definition of LADA excludes patients who require insulin within the first 6 months after diagnosis, whereas the majority (90%) of A+β+ KPD patients present with DKA as the first manifestation of diabetes and therefore require insulin at the start. there needs to be an article on Ketosis-prone diabetes, but it is not type 1.5 or type 2.0. --Bejnar (talk) 19:04, 15 October 2012 (UTC)