Talk:Cori cycle

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Molecular Biology: MCB

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Merge

The cori cycle is similar to the alanine cycle in that the requirement of energy causes molecules in the muscle to be broken down and the resulting residues are then sent to the liver for restoration to pyruvate (and usually then to glucose). However the cori cycle is initiated by the anaerobic oxidation of pyruvate in response to exercise (carbohydrate metabolism) and the resulting high blood lactic acid concentrations, whereas the alanine cycle is initiated by the body degrading protein stores (protein metabolism) to the amino acids alanine and glutamine in order to maintain blood glucose levels when no glucose is available in the diet and the glycogen stores have been exhausted. The reasons behind each are different though organs and final products involved are similar. The methods can be compared but should not be merged as they ARE different pathways involving different intermediates.

Agreed, I don't think this is a candidate for a merger without further reasoning - unless that merged was into a more general article. Orchid Righteous 11:06, 24 August 2006 (UTC)[reply]

The diagram has the arrow for 2ATP pointed in the wrong direction!!! —Preceding unsigned comment added by Nieves.felipe (talk • contribs) 05:08, 7 November 2009 (UTC)[reply]

Lactic Acidosis and Muscle Fatigue

From the most recent literature reviews I have read, it appears that many exercise physiologist believe that once common belief that lactic acidosis causes muscle fatigue/pain/cramps is incorrect.

As found in "Skeletal Muscle Fatigue: Cellular Mechanisms," (D. G. Allen, et al, Physiol. Rev. 88: 287-332, 2008, http://physrev.physiology.org/cgi/content/full/88/1/287)

"The traditional explanation, accumulation of intracellular lactate and hydrogen ions causing impaired function of the contractile proteins, is probably of limited importance in mammals."

This issue is addressed in the wikipedia article on lactic acid. The claim that "the accumulation of lactic acid causes muscle pain and cramps; however, normally before this happens the lactic acid is moved out of the muscles into the liver" should probably be corrected in this article. Mahasanti (talk) 19:00, 3 June 2008 (UTC)[reply]

Anaerobic respiration

Glycolysis and fermentation are not "respirations" strictly speaking. Anaerobic respiration is a bacterial process. It is the same as an aerobic respiration but it doesn't use oxygen as electron acceptor but another substance (for instance, nitrate). You can read the link in wikipedia from your article. Cory cycle in muscle during intense activity is an anaerobic process also but it is not a "respiration" properly speaking. Here, it is better to say fermentation rather than anaerobic respiration.--Miguelferig (talk) 15:10, 20 May 2012 (UTC)[reply]

6 v 2

So you only get 2 ATP from glucose > pyruvate but need 6 to rebuild it? What happens to the 4 difference? Burned up? 64.228.90.179 (talk) 23:40, 6 November 2015 (UTC)[reply]

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Glycolysis yields 2 ATP or 3 ATP ?

I've read that glycolysis, using glycogen as starting point, will yield 3 ATP rather than 2, because glucose 6-phosphate is produced directly, and a reaction is spared. I've read this in Lehninger Principles of Biochemistry, 4th Edition, pag. 898. What do you say? Stingaciu Radu N. 23:19, 10 October 2021 (UTC) — Preceding unsigned comment added by GratarGratar (talk • contribs)