Talk:Ciramadol

Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Ciramadol.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Buprenorphine

Does anybody know how similar or dissimilar this drug is to buprenorphine? As they are both mixed agonist-antagonists at the mu receptor, and both have dose ceilings, they seem quite simiilar. Should this simiilarity perhaps be mentioned on the page? Spiral5800 (talk) 14:31, 5 December 2009 (UTC)[reply]

Derivatives

The diethyl, piperidine & morpholine analogues are all seen on Chemspider. All appear to be mixed agonist/antagonists but it means that the N-substituents have been studied.

Burgemeister, T., Ozarslan, O., Ertan, M., Akgun, H., & Wiegrebe, W. (1994). Aminocyclanols.2. Stereochemical studies on a new ciramadol analog by nmr-spectroscopy. Archiv Der Pharmazie, 327 (12), 785-787 https://epub.uni-regensburg.de/15874/1/ubr04143_ocr.pdf

I also saw a p-Cl in place of the m-phenolic group in Reaxys but couldn't get the paper. In all cases, too expensive & complex to be produced in commercial volumes. 3 Chiral centers! This one MIGHT be a pure agonist.