Talk:Childhood leukemia

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 26 November 2018 and 21 December 2018. Further details are available on the course page. Student editor(s): Cejohns2018. Peer reviewers: Andresprk.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 18:58, 17 January 2022 (UTC)

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 28 January 2019 and 17 May 2019. Further details are available on the course page. Student editor(s): Kaynat08.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 18:58, 17 January 2022 (UTC)

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Mirandalgreen.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:26, 16 January 2022 (UTC)

Ideas to add, please give feedback

I am working on this article as part of my WR-121 class. I have a few ideas and things I would like to address, and would like to talk about them here for feedback. I am a first year college student and haven't taken a writing course in multiple years, so any feedback and constructive criticism is appreciated. Lets get started.

Basically, as prior people in the talk section suggested, I want to make the article more sophisticated and supported by more reliable sources. I plan on reviewing medical journals and textbooks, along with reliable websites. The topics I want to cover/add are some statistics on survival/death rate from the treatment and cancer. I also plan on adding long/short term effects and general side effects of the treatment and cancer itself. I believe adding some methods of coping and what families have done to get past this huge obstacle in life and overcome this disease. Although its not something used often, or recommended, I would like to also cover natural and homeopathic remedies that people may try at home. I intend to also review all the topics currently addressed and go more in depth and cover them a little better.

This will be my first attempt, and I will be putting a lot of thought and time(as much as my class allows) into this article. Any suggested sources would be appreciated! Holbrook.alex98 (talk) 20:48, 21 July 2018 (UTC)Holbrook.alex98

This article has a long way to go

This has been compiled from very basic patient information, written on about the 9th grade level, and it doesn't even give inline sources. WP:MEDMOS says that we're not writing for patients (although patients do educate themselves about their disease from WP and that's one of our purposes).

It should be rewritten from more sophisticated sources, like a medical journal review articles and medical textbooks (at least the Merck Manual).--Nbauman (talk) 21:03, 1 November 2011 (UTC)

Japanese

Here is the equivalent section within the leukemia article in Japanese: http://ja.wikipedia.org/wiki/%E7%99%BD%E8%A1%80%E7%97%85#.E5.B0.8F.E5.85.90.E7.99.BD.E8.A1.80.E7.97.85 — Preceding unsigned comment added by 12.235.122.130 (talk) 00:01, 16 November 2013 (UTC)

Here's the Google Translate version:

Childhood leukemia Epidemiology of childhood leukemia

Slightly less in Asia in Japan develop three to about 100,000 people a year leukemia in children in Europe and the United States 4 per 100,000 children per year [ 141 ] , [ 142 ] . In pediatric Japan are being treated in the pediatric children about 700-800 people a year develop leukemia [ Note 31] [ 141 ] . The incidence of childhood leukemia is about half the incidence of adult whole but slightly more in boys ( male to female ratio = 1.35 ) of it is the same as adult . The characteristic in children leukemia ( about 5% ) , are mostly acute leukemia chronic leukemia is small , acute lymphocytic leukemia and 80 % are (ALL). Percentage of myeloid is reversed : lymphocytic in children and adults (AML) because there are many acute myeloid leukemia in adults . AML is developed at any age in childhood leukemia , but the onset is often in boys 2-3 years in ALL [143]. Features of childhood leukemia

60-80 percent healed acute lymphoblastic leukemia in children , it is prognosis is better than adult leukemia in childhood leukemia overall , the prognosis so good in the older children of 10 years of age or older and infants under 1 year of age no . Type of genetic mutation that caused the leukemia Although there are many , gene mutation type good prognosis often in children of 2-9 years different types of gene mutations are common by age infants under 1 year of age there is a tendency that the proportion of type of leukemia prognosis is better low age increases with the exception [ 143 ] . However , the fact remains that it is a serious disease to say what a good prognosis is often childhood leukemia . 20-25 percent (in which chromosome is increased to 50 or more ) high- diploid , TEL-AML1 fusion gene was observed in 15-20 % , chromosomal and genetic abnormalities in acute lymphoblastic leukemia in children of two prognosis is good leukemia by chromosomal and genetic abnormalities . Chromosomal and genetic abnormalities with poor prognosis (MLL-AF4 fusion gene BCR-ABL fusion gene (or Philadelphia chromosome Ph +),) is 5% , the middle group is a little less than 50% in reverse . In acute myeloid leukemia in children is a prognosis intermediate group 40-60 % are long-term survival , most healing [ 143 ] . (TEL-AML1 fusion gene or high diploid ) ALL types of good prognosis has many leukemia 2-4 year-old children account for the majority of childhood leukemia in the number of people , but it of older children is a few in the entire in the leukemia rate of ALL types of good prognosis less and less , ( not the same thing as worse than ALL of the adult but ) it is considered a high-risk leukemia leukemia over the age of 10 [ 144 ] . However , assessing the poor prognostic factor is important leukemia types of poor prognosis in leukemia of 2-4 year-old children because there Some of them . Leukemia of infants under 1 year of age is 5-10% of childhood leukemia , ALL with the MLL-AF4 fusion gene was observed in about half of nature is strong medical transplantation very bad ALL with the MLL-AF4 fusion gene has been recommended [ 143 ] . Treatment of childhood leukemia

I do the treatment of four-phase of remission induction therapy , sanctuary therapy , intensive therapy and maintenance therapy in the treatment of ALL in children . Aiming for remission in two drugs Bingurisuchin and prednisolone (trade name Oncovin ) in remission induction therapy . That leukemia cells infiltrate the central nervous Many in ALL, such as cranial irradiation is carried out and a large dose of intrathecal methotrexate , in some cases as a sanctuary therapy for the treatment or prevention of central nervous system leukemia . Is performed cytarabine and polypharmacy and ( km side ) large doses in the intensive therapy aimed at eradication of leukemia cells remaining , and oral methotrexate and 6-MP as maintenance therapy in order to keep the leukemia cells that could survive any chance I continue for about 1-2 years . When you have got any chance or recurrence type and poor prognosis to examine the medical transplantation and [ 143 ] . Donor is easy to obtain compared to adult hematopoietic stem cells of a sufficient number can be obtained for transplantation in the bone marrow of petite women and umbilical cord blood low number of cells the body is small in children . Performance is not as good as ALL the treatment of AML in children , but using the anthracycline anticancer agent ( km side ) cytarabine , induction aims to complete remission with intensive therapy and maintenance therapy . Central nervous system leukemia less so in AML doing intrathecal anti-cancer agents prophylactic low [ 143 ] . In addition, the drugs listed above is an anti- cancer agent other than prednisolone . Down syndrome childhood leukemia

That it blood abnormalities variety occurs often in children with Down syndrome are known , leukemia also shows the incidence of 15 times the non- Down syndrome children . It presents a state similar to leukemia temporarily often in neonates with Down syndrome . Most of them heal spontaneously in a few months , but the child with Down's syndrome Some develop (AML-M7) acute megakaryoblastic leukemia . That become (AML-M7) acute megakaryoblastic leukemia in children with Down syndrome under the age of 3 large specifically compared to non- down children . The down children under 3 years later incidence rate trend is also the same as the non- Down syndrome children and [ 145 ] .

This has some interesting information that ought to be included here (with suitable sources). WhatamIdoing (talk) 04:31, 18 November 2013 (UTC)

Ideas/Work Plan for Update, Please give feedback!

Hi all, I am a 4th year medical student working on this page as part of a class focused on expanding Wikipedia! I have some ideas and any feedback is welcome! I think the article has great hyperlinking and the references are generally solid but can be expanded upon and updated.

One of the larger things I plan to change is further delineating that childhood leukemia is an umbrella term for multiple diseases, most commonly ALL (as emphasized in the article currently) and AML. I think it would be useful to address this earlier as the different forms of the leukemia have varied prognoses and treatments. I'd also like to add sources and information to some of the sections (Symptoms, Types of Leukemia, and Diagnosis) and add a sections on Epidemiology and Prognosis. Here is my timeline:

-11/28-11/29: Create timeline, begin to gather sources on childhood leukemia, childhood AML and childhood CLL, edit format of page headings (add Epidemiology section, Prognosis section, reorder so that Types of Leukemia is higher).

-12/1-12/5: Edit Types of Leukemia section and add citations. Edit Lead section with focus on making it more generalized. Edit Symptoms section and add sources.

-12/6-12/10: Edit diagnosis section and add sources. Create Epidemiology section. Create Prognosis section.

-12/11-12/14: Edit treatment section to reflect AML and ALL treatment. Expand on after-effects section. Receive peer edit.

-12/14-12/21: Respond to peer edits. Catch up on things I was not able to get to. If I have achieved this, then I may edit the Causes section and include some information on genetics in childhood Leukemia.

Any feedback is appreciated. Thanks! Cejohns2018 (talk) 17:34, 8 December 2018 (UTC)

Hello! Thank you for sharing such a detailed plan! I just reviewed parts of the article and wanted to share thoughts—

- Overall: Words were appropriate and easily understandable. Since this is a more general page about childhood leukemia overall, I thought the short descriptions of each of the types of leukemia with corresponding links to each specific page was appropriate and effective.

- In terms of overall organization, I found the manual of styles for medicine related articles to be extremely helpful for organizing sections: https://en.wikipedia.org/wiki/Wikipedia:Manual_of_Style/Medicine-related_articles

- I thought the epidemiology and prognosis sections were extremely informative but could benefit from more citations. I would try to add more citations throughout these two sections.

Andresprk (talk) 22:53, 11 December 2018 (UTC)andresprk

Thanks for your feedback! I'll try to make some edits regarding the manual style and citations this week. If I am not able to finish it, I think these points and editing the causes section would be a good spot for another person to pick up!

Cejohns2018 (talk) 00:44, 19 December 2018 (UTC)