Talk:Carcinoid syndrome

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I think that you should change the survival times--I was told that by a doctor at the Mayo Clinic in 2000 that the median survival from diagnosis was 7 years. If you check the online support groups you will hear of people surviving more than 20 years after diagnosis of liver metastases and onset of symptoms. --216.137.70.192 08:54, 7 January 2006. Moved from main article --82.16.57.133 19:59, 12 January 2006 (UTC)

The initial lines are also innaccurate - they state that carcinoid tumours occur in the G.I. tract but in fact they can also occur elsewhere e.g. the lung and even other organs. A very good source of information is www.carcinoid.org or www.netumoradvisor.org

There are inaccuracies in the pathophysiology section. Carcinoid tumors commonly make serotonin but not histamine or catecholamines. The vasoactive manifestations, most notably the flushing, result fromsecretion of kallekrein, the enzyme that catalyzes the conversion of kininogen to lysyl-bradykinin. The latter is further converted to bradykinin, one of the most powerful vasodilators known. Bradykinin, not serotonin, is the cause of the flushing.--BobL 18:36, 3 November 2006 (UTC)

detection

There are non-invasive imaging modalities for finding Carcinoid, including: Iodinated (I-123 or I-131) metaiodobenzylguanidine (MIBG), or Indium pentatreotide (>80% sensitivity). 66.57.77.120 02:27, 25 April 2007 (UTC)

- Question - I noticed during pathology lesson that, as you write in this article carcinoid tumors are yellow. Which substance in the cells causes the colour? My pathology professors had no answer, perhaps I should ask a biochemist... 81.209.175.112 18:20, 8 May 2007 (UTC)

how to naturally lower seratonin

Are there any ways to naturally lower seratonin? This disease and others are associated with high levels of seratonin and there should be some way to lower it naturally.

"Some patients with carcinoid may lack the metabolic machinery to convert serotonin to 5-HIAA, so they have high blood levels of serotonin but normal urinary 5-HIAA." writes the Cleveland Medical Clinic. <http://www.clevelandclinicmeded.com/diseasemanagement/endocrinology/flushing/flushing.htm> So basically, some people's bodies can't break down seratonin... and it adds up in their bodies. Would this be considered a genetic disease?

Carcinoid and Migraines

Has this occurred to anyone: -there is excessive vasodilation that occurs in carcinoid syndrome -there are new forms of migraine medicine called "triptans" that include medicine such as imitrex that have vasoconstrictive actions. -maybe that subject should be researched more and it seems that if you treat the person with vasoconstrictors it would improve some of the symptoms that carcinoid syndrome patients have that include frequent headaches.

I doubt they would be a good treatment, for one they target specifically serotonin receptors in the brain and are agonists. I do not think you want to have a 5ht agonist working in a high serotonin environment, not to mention you might risk serotonin syndrome. The better option, which is also FDA approved for carcinoid syndrome is octreotide. — Preceding unsigned comment added by 201.220.15.68 (talk) 20:25, 6 November 2011 (UTC)

Removal

Niacin could possibly reverse carcinoid cancer.

Unsourced and dubious statement. Kpjas (talk) 07:44, 29 September 2008 (UTC)

Hello

Hello all, I am a m4 student editing this article as part of a WikiProject Medicine class. Below are my goals for edits over the next few weeks:

1. Review and update sources
2. provide more background information in the pathophysiology section
3. provide a more full and precise signs and symptoms section
4. Discuss more in the treatment section and try to provide links to other relevant wikipedia articles
5. Potentially other clarifications and summary edits as necessary

This is my first time editing wikipedia articles so I look forward to any and all guidance and suggestions! JackNagam (talk) 19:02, 11 January 2023 (UTC)

Wiki Education assignment: WikiProject Medicine Winter 2023 UCF COM

This article was the subject of a Wiki Education Foundation-supported course assignment, between 9 January 2023 and 3 February 2023. Further details are available on the course page. Student editor(s): JackNagam (article contribs). Peer reviewers: Med2023.

— Assignment last updated by DLEMERGEBM (talk) 00:29, 27 January 2023 (UTC)

Lead section:

Consider rephrasing the second sentence to “Neuroendocrine tumors release biological factors into the blood which results in symptoms such as … “ so that a layman wouldn’t assume that the tumor originates in the blood.

Signs and symptoms:

Consider changing “the carcinoid syndrome” to “carcinoid syndrome” for consistency.

Bullet point on flushing: Edit “activity, stress” to “activity, and stress.”

Bullet point on heart disease = Clarify “This mainly affects the right side of the heart causing fibrosis of the tricuspid and pulmonic valves” to “About 25% of neuroendocrine tumors arise in the respiratory tract, so the symptom-inciting metabolites from them will travel to the right-side of the heart instead of undergoing first-pass metabolism by the liver. This leads to fibrosis of the tricuspid and pulmonic valves and lead to cardiac complications, murmur, and fatigue. The metabolites are then metabolized in the lungs before reaching the left side of the heart”

Pathophysiology:

Consider changing “the carcinoid syndrome” to “carcinoid syndrome” for consistency.

Consider editing the second sentence to put the top two neuroendocrine locations together since they make up the majority. I’ve copied some information here in case you want to make this change (https://www.ncbi.nlm.nih.gov/books/NBK448096/) - “Neuroendocrine tumors mostly arise in the gastrointestinal (GI) tract (about 70%) followed by respiratory tract (about 25%).[2] Neuroendocrine tumors can rarely arise from other areas like ovaries, testicles, and kidneys.”

Diagnosis:

Excellent, I can’t recommend any changes.

Treatment:

Consider rephrasing the first two sentences as “Treatment is focused on controlling the proliferation of neuroendocrine tumors and subsequently symptoms associated with carcinoid syndrome. Current management strategies include the use od somatostatin analogues such as octerotide or lanreotide.

Great article!

It seems like it’ll be easily understood by the intended audience. Most sources are secondary sources and links are functional. You’ve met the goals of your workplan. The structure of the article flows understandably.

You’ve done great work! Please feel free to make changes based on the suggestions above if appropriate; regardless, you’ve made a great contribution to Wikipedia and I learned a lot from your article. Thank you for writing this! Med2023 (talk) 18:40, 31 January 2023 (UTC)

Thanks for the feedback! I generally agree and have made changes based on your suggestions. I reviewed your suggestions for the cardiac signs and symptoms and decided to leave my current section as is because I feel the changes fit more in the pathophysiology section where there is already a brief blurb stating the same thing. JackNagam (talk) 14:54, 2 February 2023 (UTC)