Talk:C3a (complement)

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I made edited this page and sent prospective edits to Immcarle3 in a word documentImmcarle4 (talk) 20:08, 1 March 2016 (UTC)[reply]

Useful articles about C3a

For my immunology class, we are editing a relevant stub. Here are a few articles I have looked at so far:

Merle, NS; Noe, R; Halbwachs-Mecarelli, L; Fremeaux-Bacchi, V; Roumenina, LT (2015). "Complement System Part II: Role in Immunity.". Frontiers in immunology 6: 257. PMID 26074922.

Strainic, MG; Liu, J; Huang, D; An, F; Lalli, PN; Muqim, N; Shapiro, VS; Dubyak, GR; Heeger, PS; Medof, ME (March 2008). "Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.". Immunity 28 (3): 425–35. PMID 18328742

Sacks, SH (March 2010). "Complement fragments C3a and C5a: the salt and pepper of the immune response.". European journal of immunology 40 (3): 668–70. PMID 20186746

Leslie, JD; Mayor, R (February 2013). "Complement in animal development: unexpected roles of a highly conserved pathway.". Seminars in immunology 25 (1): 39–46. PMID 23665279

Lambris, JD; Tsokos, GC (1986). "The biology and pathophysiology of complement receptors.". Anticancer research 6 (3 Pt B): 515–23. PMID 2943215

Prospective Lead Section & Changes

C3a is a protein formed by the cleavage of complement component 3. C3a is a 77 residue helix made up of a four-helix bundle fold^[1] with a molecular mass of about 10 kDa^[2].

C3a is an anaphylatoxin effector of the complement system with a range of functions including T cell activation and survival^[3], angiogenesis stimulation^[4], and macrophage activation^[5]. It has been shown to have both proinflammatory and anti-inflammatory responses, its activity able to counteract the proinflammatory effects of C5a^[6]. It has also been shown to regulate monocyte production of IL-1β^[7].

C3a molecules induce responses through the GPCR C3a receptor. Like other anaphylatoxins, C3a is regulated by cleavage of its carboxy-terminal arginine, resulting in C3a desarginine, which possesses lowered biological functions^[8].

Potential Sections:

Structure of C3a

Discuss X-ray structures and 3D structures

Formation of C3a

Regulation of C3a

Talk about regulation by carboxypeptidase B (C3a desArg)

Functions of C3a

Go through a comprehensive list of its functions (immunological and otherwise)

References

^ Bajic, G; Yatime, L; Klos, A; Andersen, GR (February 2013). "Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg". Protein science : a publication of the Protein Society. 22 (2): 204–12. PMID 23184394.
^ Zhou, W (February 2012). "The new face of anaphylatoxins in immune regulation". Immunobiology. 217 (2): 225–34. PMID 21856033.
^ Strainic, MG; Liu, J; Huang, D; An, F; Lalli, PN; Muqim, N; Shapiro, VS; Dubyak, GR; Heeger, PS; Medof, ME (March 2008). "Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells". Immunity. 28 (3): 425–35. PMID 18328742.
^ Khan, MA; Assiri, AM; Broering, DC (22 July 2015). "Complement and macrophage crosstalk during process of angiogenesis in tumor progression". Journal of biomedical science. 22: 58. PMID 26198107.
^ Mathern, DR; Heeger, PS (4 September 2015). "Molecules Great and Small: The Complement System". Clinical journal of the American Society of Nephrology : CJASN. 10 (9): 1636–50. PMID 25568220.
^ Coulthard, LG; Woodruff, TM (15 April 2015). "Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth". Journal of immunology (Baltimore, Md. : 1950). 194 (8): 3542–8. PMID 25848071.
^ Triantafilou, M; Hughes, TR; Morgan, BP; Triantafilou, K (February 2016). "Complementing the inflammasome". Immunology. 147 (2): 152–64. PMID 26572245.
^ . PMID 16112742. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

[1] Bajic, G; Yatime, L; Klos, A; Andersen, GR (February 2013). "Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg". Protein science : a publication of the Protein Society. 22 (2): 204–12. PMID 23184394.

[2] Zhou, W (February 2012). "The new face of anaphylatoxins in immune regulation". Immunobiology. 217 (2): 225–34. PMID 21856033.

[3] Strainic, MG; Liu, J; Huang, D; An, F; Lalli, PN; Muqim, N; Shapiro, VS; Dubyak, GR; Heeger, PS; Medof, ME (March 2008). "Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells". Immunity. 28 (3): 425–35. PMID 18328742.

[4] Khan, MA; Assiri, AM; Broering, DC (22 July 2015). "Complement and macrophage crosstalk during process of angiogenesis in tumor progression". Journal of biomedical science. 22: 58. PMID 26198107.

[5] Mathern, DR; Heeger, PS (4 September 2015). "Molecules Great and Small: The Complement System". Clinical journal of the American Society of Nephrology : CJASN. 10 (9): 1636–50. PMID 25568220.

[6] Coulthard, LG; Woodruff, TM (15 April 2015). "Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth". Journal of immunology (Baltimore, Md. : 1950). 194 (8): 3542–8. PMID 25848071.

[7] Triantafilou, M; Hughes, TR; Morgan, BP; Triantafilou, K (February 2016). "Complementing the inflammasome". Immunology. 147 (2): 152–64. PMID 26572245.

[8] . PMID 16112742. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

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