Talk:Bivalirudin
 | This article is rated Start-class on Wikipedia's content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||
| |||||||||||||||||||||
 | Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Bivalirudin.
|
WikiProject class rating
[edit]This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:24, 10 November 2007 (UTC)
Indications
[edit]We often use bival for HIT; is this an official indication? If so, it's not listed. Obviously this might just be the standard off-label sort of thing... 71.248.114.201 (talk) 20:06, 9 November 2008 (UTC)
needs updating according to new study results?
[edit]why does the page say "Bivalirudin ... overcomes many limitations seen with indirect thrombin inhibitors, such as heparin" when Bivalirudin was inferior to heparin in both efficacy and safety in a recent study published in the lancet: Shahzad et al. 2014. Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial. — Preceding unsigned comment added by Andywhatever (talk • contribs) 00:37, 8 December 2015 (UTC)
External links modified
[edit]Hello fellow Wikipedians,
I have just added archive links to one external link on Bivalirudin. Please take a moment to review my edit. If necessary, add {{cbignore}} after the link to keep me from modifying it. Alternatively, you can add {{nobots|deny=InternetArchiveBot}} to keep me off the page altogether. I made the following changes:
- Added archive https://web.archive.org/20120426012238/http://angiomax.com/Downloads/Angiomax_PI_2010_PN1601-12.pdf to http://angiomax.com/Downloads/Angiomax_PI_2010_PN1601-12.pdf
When you have finished reviewing my changes, please set the checked parameter below to true to let others know.
This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 5 June 2024).
- If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
- If you found an error with any archives or the URLs themselves, you can fix them with this tool.
Cheers.—cyberbot IITalk to my owner:Online 14:59, 16 January 2016 (UTC)
External links modified
[edit]Hello fellow Wikipedians,
I have just modified 2 external links on Bivalirudin. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
- Added archive https://web.archive.org/web/20120426012235/http://www.themedicinescompany.com/new-images/Angiox-PIs/emea-combined-h562en.pdf to http://www.themedicinescompany.com/new-images/Angiox-PIs/emea-combined-h562en.pdf
- Added archive https://web.archive.org/web/20150203135952/http://angiomax.com/downloads/Angiomax_US_PI_June_2013.pdf to http://www.angiomax.com/downloads/Angiomax_US_PI_June_2013.pdf
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 5 June 2024).
- If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
- If you found an error with any archives or the URLs themselves, you can fix them with this tool.
Cheers.—InternetArchiveBot (Report bug) 04:52, 21 July 2017 (UTC)
Ambiguity pitfall in the term "reversible"
[edit]I've removed language in a couple of places (one of them in the first sentence of the lead section) that called bivalirudin "reversible", although I've left in place the explanation in the section "Basic chemical and pharmacological properties", which makes it clear that the term "reversible" refers to the mode of binding at the molecular level. The language "reversible" in other places misleadingly suggests the existence of a specific clinical reversal agent (antidote) that would reverse the clinical effects of bivalirudin, in the way that idarucizumab (Praxbind) reverses the effects of dabigatran (Pradaxa). No such specific clinical reversal agent exists for bivalirudin, and it is potentially dangerous to lead readers to think it does.
The "reversible" claim is from the manufacturer's prescribing information for bivalirudin, which presumes a professional readership. This is an illustration of the pitfalls of using language from professional literature directly in a source like Wikipedia, whose intended audience is the general public.