Talk:Biopharmaceutical/to do
This list is incomplete, please discuss and add more.
- Biopharmaceutical development (see: drug development) and approval process (preferably fow-sheet):
- Rational drug design and combinatorial chemistry approach (in brief)
- Patenting of biopharmaceuticals (USPTO, EPO, etc)
- Classification:
- Nucleic acid therapeutics (Gene therapy, antisense technology, etc.)
- Recombinant proteins: Subunit vaccine
- Antibody based therapeutics: monoclonal antibodies, etc.
- Delivery (see: drug delivery):
- Oral, pulmonary, nasal, transmusocal and transdermal delivery systems.
- Uses:
- ...
- Focus: Development of AIDS vaccine (see: HIV vaccine).
- Focus: Gene therapy and cancer (also AIDS).
- Large scale production:
- Details of platforms i.e. mammalian cell, yeast cells, insect cell, plant cell culture and whole-plants.
- Their relative advantages and disadvantages (preferably in tablular form).
- to include biological production of hormones, interferons, etc from genetically engineered cells (pathways, sources, cell line).
- Downstream processing (filtration, etc)
- Others:
- Proteomics in biopharmacetical drug development and diagnosis of disease.
- Enzymes in clinical diagnostics (clinical enzymology) - biosensors - microanalysis kit development.
- Purity, efficacy, potency, safety, cost, etc.:
- Regulation by authorities like US FDA, European Commission, etc.
- Ethics: public concern in
- Gene therapy (in vivo): human germ line
- Genetic modification of plants and animals for our benefit
- Cost vs. degree of action
- Acceptance by society:
- Factors involved...
- Business of biopharmaceuticals:
- Industry statistics (sales, etc.)
- Companies (Amgen, Biogen, Genentech, Boehringer Ingelheim, etc.)
- ...
- ...
- References:
- ...
- External links:
- Please add
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