Talk:Biology of obsessive–compulsive disorder

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 7 January 2019 and 26 April 2019. Further details are available on the course page. Student editor(s): EmilyNorwood. Peer reviewers: Dhrunil9.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 15:46, 16 January 2022 (UTC)[reply]

Speedy deletion

How in the world is this a G12? This is a legitimate WP:SPINOFF from another article: bam, bam. Cosmic Latte (talk) 20:15, 26 July 2009 (UTC)[reply]

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Male ArKO mice increase repetitive behaviors such as wheel running and grooming, in comparison to normally developed mice. These repetitive and obsessive-like behaviors revert to typical levels with 17beta-estradiol replacement therapy, providing even more evidence that low levels of estrogen increases risk for OCD behaviors in males.^[1]

Male ArKO mice also showed a decrease in levels of catechol-O-methyl transferase (COMT) protein.^[1] Low levels of COMT protein are associated with susceptibility to OCD, especially within human males.^[1] While a decrease in estrogen levels in males shows an increase in OCD behaviors, females show the opposite effect.

Low estrogen levels in turn lead to behavioral changes that have been displayed in obsessive compulsive disorder (OCD) in humans.^[2] Studies within rats further investigated this correlation, finding that OCD behavior varied during the estrous cycle, being highest at late diestrus and proestrus when estrogen levels are highest, and lowest after estrogen has decreased.^[3] in addition, women with OCD have reported changes in the intensity and occurrences of their symptoms during their premenstrual and menstrual period, after pregnancy, and following menopause.^[4] Research found that the absence of estrogen in ArKO female mice decreased barbering (cleaning), wheel running, and grooming tendencies associated with OCD behavior.^[3] This correlates with other findings that increased levels of estrogen increase OCD behaviors in females.

References

^ ^a ^b ^c Hill, Rachel A.; McInnes, Kerry J.; Gong, Emily C.H.; Jones, Margaret E.E.; Simpson, Evan R.; Boon, Wah Chin (2007). "Estrogen Deficient Male Mice Develop Compulsive Behavior". Biological Psychiatry. 61 (3): 359–66. doi:10.1016/j.biopsych.2006.01.012. PMID 16566897.
^ Alonso, P.; Gratacòs, M.; Segalàs, C.; Escaramís, G.; Real, E.; Bayés, M.; Labad, J.; Pertusa, A.; Vallejo, J.; Estivill, X.; Menchón, J.M. (2011). "Variants in estrogen receptor alpha gene are associated with phenotypical expression of obsessive-compulsive disorder". Psychoneuroendocrinology. 36 (4): 473–83. doi:10.1016/j.psyneuen.2010.07.022. PMID 20850223.
^ ^a ^b Flaisher-Grinberg, Shlomit; Albelda, Noa; Gitter, Liron; Weltman, Keren; Arad, Michal; Joel, Daphna (2009). "Ovarian hormones modulate 'compulsive' lever-pressing in female rats". Hormones and Behavior. 55 (2): 356–65. doi:10.1016/j.yhbeh.2008.10.002. PMID 18996389.
^ Cite error: The named reference Boon, W. C., & Horne, M. K. 2011 816–819 was invoked but never defined (see the help page).

[Hill,_R._A.,_McInnes,_K._J.,_Gong,_E._C._H.,_Jones,_M._E._E.,_Simpson,_E._R.,_&_Boon,_W._C._2007_359–366-1] Hill, Rachel A.; McInnes, Kerry J.; Gong, Emily C.H.; Jones, Margaret E.E.; Simpson, Evan R.; Boon, Wah Chin (2007). "Estrogen Deficient Male Mice Develop Compulsive Behavior". Biological Psychiatry. 61 (3): 359–66. doi:10.1016/j.biopsych.2006.01.012. PMID 16566897.

[2] Alonso, P.; Gratacòs, M.; Segalàs, C.; Escaramís, G.; Real, E.; Bayés, M.; Labad, J.; Pertusa, A.; Vallejo, J.; Estivill, X.; Menchón, J.M. (2011). "Variants in estrogen receptor alpha gene are associated with phenotypical expression of obsessive-compulsive disorder". Psychoneuroendocrinology. 36 (4): 473–83. doi:10.1016/j.psyneuen.2010.07.022. PMID 20850223.

[Flaisher-Grinberg,_S.,_Albelda,_N.,_Gitter,_L.,_Weltman,_K.,_Arad,_M.,_&_Joel,_D._2009_356–365-3] Flaisher-Grinberg, Shlomit; Albelda, Noa; Gitter, Liron; Weltman, Keren; Arad, Michal; Joel, Daphna (2009). "Ovarian hormones modulate 'compulsive' lever-pressing in female rats". Hormones and Behavior. 55 (2): 356–65. doi:10.1016/j.yhbeh.2008.10.002. PMID 18996389.

[Boon,_W._C.,_&_Horne,_M._K._2011_816–819-4] Cite error: The named reference Boon, W. C., & Horne, M. K. 2011 816–819 was invoked but never defined (see the help page).

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