Talk:Binding selectivity

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A fact from Binding selectivity appeared on Wikipedia's Main Page in the Did you know column on 2 April 2010 (check views). The text of the entry was as follows:

Did you know... that binding selectivity is of major importance in biochemistry and in chemical separation processes?

A record of the entry may be seen at Wikipedia:Recent additions/2010/April.

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Could somebody please improve the lead

Its first sentence reads, "Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex." That is a comment about the term "binding selectivity," rather than an explanation of what it means. It's analogous to "Fuel efficiency is defined with respect to the combustion of gasoline by an automobile," which—I hope we all can agree—would not be a very good first sentence for the article on fuel efficiency.

Its second sentence begins, "A selectivity coefficient is the..." But this introduces out of the blue the idea of coefficients. If coefficients are in fact the article's subject, then coefficient ought to figure in the article's title.

As Wikipedia's essay 'Writing better articles' advises, the first sentence of an article "should give a concise definition: where possible, one that puts the article in context for the nonspecialist. Similarly, if the subject is a term of art, provide the context as early as possible."

I'd fix it myself, but I'm one of the nonspecialists who came to the article seeking enlightenment.—PaulTanenbaum (talk) 20:41, 1 September 2015 (UTC)[reply]