Talk:Belimumab

Target

I think it is B lymphocyte stimulator, not really anti-TNF. Regards, Blake3522 09:47, 13 July 2007 (UTC)

Side effects etc

It would be greatly appreciated to know data that we are told about other medications, such as side affects, method of ingestion (pill, injection, IV, etc.) and any other info that is usually included in a drug description for the layman. —Preceding unsigned comment added by Penlady (talk • contribs) 21:54, 21 June 2009 (UTC)

I second the idea of adding in information regarding side effects and clinical trials so as to better educate visitors about this drug. It's vital given that it's been a long while before any major drug has been released that specifically targeted lupus. Kinsho 06:32, 25 December 2009 (UTC)

Clinical trial endpoint

It should be noted that the clinical trial endpoint was rigourous: 'At Wk52, the percent of subjects with ≥ 4 point reduction from baseline in SELENA SLEDAI score and no worsening in PGA and no new BILAG A organ domain score or 2 new BILAG B organ domain scores compared with baseline at the time of assessment.' Patients can experience clinical benefit while not making all these criteria; this is one of the basic differences between clinical research and ordinary medicine. Cranham 13 Mar 2011

Yes, they can benefit even if the results are negative, but then, they might not benefit. We can't tell, and saying "people might benefit, or maybe not" isn't really valuable information. --ἀνυπόδητος (talk) 10:48, 14 March 2011 (UTC)

30 October 2000

Under history, there is a sentence that just says On 30 October 2000 "Human Genome Sciences and Cambridge Antibody Technology Commit to Exclusive Development of Anti-BLyS Antibodies". Is this supposed to be a reference to the sentence before and they should therefore be combined? Cleanelephant (talk) 20:16, 6 December 2011 (UTC)

NEJM

Good recent review article:

Bevra Hannahs Hahn (April 18, 2013). "Clinical Therapeutics: Belimumab for Systemic Lupus Erythematosus". N Engl J Med. 368: 1528–1535. doi:10.1056/NEJMct1207259. --Nbauman (talk) 04:38, 19 April 2013 (UTC)

Free access NEJM blog summary:

http://blogs.nejm.org/now/index.php/belimumab-for-sle/2013/04/19/

NOW@NEJM

Belimumab for SLE

Posted by Sara Fazio • April 19th, 2013

In the latest review article in our Clinical Therapeutics series, a 20-year-old woman with SLE presents with disease flares and receives belimumab, a monoclonal antibody that binds to B-cell activating factor, inhibiting B-cell stimulation. Belimumab is considered for patients who do not have a response or have adverse effects with first-line therapies.

--Nbauman (talk) 19:05, 20 April 2013 (UTC)

False copyvio positive

http://www.usmlextract.com/2013/06/belitumab.html is apparently a false positive for copyright violations on this article. It is an uncredited copy that includes at least one phrase that was added to this article in November of 2012, as well as mangled versions of characters created in the article with wiki markup. — Preceding unsigned comment added by 198.45.215.17 (talk) 16:42, 11 November 2013 (UTC)

Yes, that looks very much like USMLE is the copyright violator. --ἀνυπόδητος (talk) 11:50, 12 November 2013 (UTC)

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