Talk:Antibody-dependent enhancement

This is the talk page for discussing improvements to the Antibody-dependent enhancement article.
This is not a forum for general discussion of the article's subject.

Put new text under old text. Click here to start a new topic.
New to Wikipedia? Welcome! Learn to edit; get help.

Article policies

Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL

Archives: 1: 6 months

Medicine Low‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Low	This article has been rated as Low-importance on the project's importance scale.

Molecular Biology: MCB

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Molecular and Cell Biology task force (assessed as Mid-importance).

Viruses High‑importance

	Viruses portal This article is within the scope of WikiProject Viruses, a collaborative effort to improve the coverage of viruses on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.VirusesWikipedia:WikiProject VirusesTemplate:WikiProject Virusesvirus articles
High	This article has been rated as High-importance on the project's importance scale.

COVID-19 High‑importance

	COVID-19 portal This article is within the scope of WikiProject COVID-19, a project to coordinate efforts to improve all COVID-19-related articles. If you would like to help, you are invited to join and to participate in project discussions.COVID-19Wikipedia:WikiProject COVID-19Template:WikiProject COVID-19COVID-19 articles
High	This article has been rated as High-importance on the project's importance scale.

Nature paper on this re covid-19

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901381/#:~:text=Vaccine-associated%20enhanced%20diseases%20(VAED,vaccination%20for%20the%20same%20pathogen. "1.4.3. Vaccine platforms Numerous vaccines are under evaluation for SARS-CoV-2 and other emerging pathogens [83]. These include well established vaccine constructs used in existing licensed vaccines (protein subunit, inactivated, virus-like particle, and replicating viral vectored vaccines), and new technologies (nucleic acid, DNA or mRNA-based vaccines) that allow for the rapid development of vaccine candidates [84]. Certain vaccines may be more appropriate for specific populations, such as the elderly, children and pregnant women, compared with healthy adults. The safety, immunogenicity and efficacy of SARS-CoV-2 vaccines must be carefully evaluated prior to their use in the general population, particularly given concerns for disease enhancement and the global need for effective vaccines to control the COVID-19 pandemic."

is the only caution the paper seems to have and the paper seems to say that this "Vaccine-associated enhanced disease" has not been found in humans re covid-19

RSV

It seems like the responses to the first RSV vaccines could be ADE. https://en.wikipedia.org/wiki/Respiratory_syncytial_virus_vaccine How much clarity about that would be required before it could be included here? 222.152.28.14 (talk) 07:42, 18 December 2021 (UTC)[reply]

Punctuation and accuracy suggestions for COVID-19 section

This following sentence in italics from the current version online needs a capital "A" if it is to remain. However, this study of Cleveland Clinic health care workers from February 2022, makes the information below outdated (although technically correct, since the date below is before this study).

I believe it is better to delete the inaccurate information. However I am NOT suggesting to replace it with the study information, as more studies would provide further clarification.

Please delete this sentence or fix the starting "a" to "A":

as of 27 January 2022, there have been no observed incidents with vaccines for COVID-19 in trials with nonhuman primates, in clinical trials with humans, or following the widespread use of approved vaccines.

An alternative approach, for those concerned about ADE would be to explain why the 2023 XBB vaccines are monovalent-only - and therefore safer in the context of ADE. The strategy behind eliminating earlier strains is to prevent the possibility of ADE by not including off-target non-neutralizing antibodies from earlier strains - based on that Cleveland Clinic study data above, as well as others.

Perhaps a better second sentence is:

The updated 2023 monovalent COVID vaccines produce antibodies specific to the current XBB variants. Vaccines targeting only the currently circulating variants would minimize the hypothetical risk of ADE by excluding off-target antibodies from prior strains. LauraWalton (talk) 01:42, 2 September 2023 (UTC)[reply]