Talk:Antennapedia

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This page could be improved in a variety of ways.

First, it could expand its content in general. It should mention that Antp is not only present in Drosophila, but also other organisms. Its function varies from one organism to another, but across organisms the Antp gene is involved in body segment development and differentiation. Furthermore, it could discuss the evolution of Antp, and how it demonstrates divergence of species.

In the first paragraph, it could be more explicit that it is explaining how the Antp gene affects body segmentation development in Drosophila. It could explain that the Antp mutation has been extensively studied in Drosophila, but that is not to say that Antp gene expression does not have functions and mutations in other organisms. In fact, in spiders, down-regulation of Antp results in 10-legged spiders.

"Antennapedia also refers to a gene complex in Drosophila which is responsible for formation and differentiation of the thoracic and head segments of the fly's body." This is a confusing statement and could be changed. It could state that Antennapedia refers to a Hox gene complex in Drosophila (and other arthropods, insects, etc.) which is responsible for body segment development. In drosophila in particular, it is responsible for formation and differentiation of thoracic and head segments, and, as a result, differentiation of leg and antenna development. Beginning with this statement and then later on mentioning the gain/loss of function mutation in Drosophila could make this article less confusing for someone who is trying to understand the Hox gene Antp.

Mccoy.484 (talk) 18:48, 30 September 2014 (UTC)mccoy.484[reply]

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References

[1] ttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1206958/pdf/ge1421295.pdf

[2] ttp://www.pnas.org.proxy.lib.ohio-state.edu/content/109/13/4921.full

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