Talk:Androgen receptor

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Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 September 2020 and 14 December 2020. Further details are available on the course page. Student editor(s): LuzAreliContreras.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:17, 17 January 2022 (UTC)[reply]

Untitled

There is a Regulatory Domain of the AR-receptor. What's the function of this domain?

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 September 2019 and 12 December 2019. Further details are available on the course page. Student editor(s): Yostrerov. Peer reviewers: Annasandberg.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 14:14, 16 January 2022 (UTC)[reply]

DHEA interaction with androgen receptor

Currently, this article states:

"The androgen receptor [...] is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. "

The dehydroepiandrosterone article states that dehydroepiandrosterone "acts" on the androgen receptor directly. Does this mean that above statement is not correct? --Abdull (talk) 13:40, 21 August 2010 (UTC)[reply]

"Binding" ≡ "acts". Boghog (talk) 18:28, 21 August 2010 (UTC)[reply]

The thing is, DHT and T are not the only things which bind to the androgen receptor. Lots of stuff binds to the androgen receptor. This statement about T and DHT needs to be qualified somehow. To give some quick citations;

One exception, 16alpha-(3'-bromopropyl)-5alpha-androstane-3alpha,17beta-diol, the only compound bearing a hydroxy group at position 17beta instead of a ketone, showed a strong binding affinity for the androgen receptor (70% at 1 microM) http://www.ncbi.nlm.nih.gov/pubmed/12443041

...is not in itself an agonist steroid on LNCaP (AR(+)) (androgen receptor) cells, and its proliferative activity appears to be mediated by its transformation into A-dione and/or into epi-ADT. http://www.ncbi.nlm.nih.gov/pubmed/18082864

Of course, lots of other things bind to AR (see the {{Androgenics}} navbox at the end of the article). The statement is already qualified by the adjective "hormones" which rules out androgens that are not endogenous. Boghog (talk) 17:55, 24 June 2013 (UTC)[reply]

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Gene location mouse

The location of the AR in the mouse is identified. I thought that this article used to have the location in the human genome as well. 19? No? ( Martin | talk • contribs 00:32, 21 July 2018 (UTC))[reply]

Oops. Its on the x chromosome. PSA is on 19, as is TGFβ1 ( Martin | talk • contribs 00:38, 21 July 2018 (UTC))[reply]

Editing project

Hello, I am working on a project with my endocrinology class and I have chosen to edit this page. My hope is to further develop this page and make it better. I welcome you to review my edits and provide me constructive criticism and feedback as this is my first time editing on wikipedia. Looking forward to learning as much as I can from this opportunity! Yostrerov (talk) 19:32, 5 October 2019 (UTC)[reply]

The "Clinical Significance" section seems to cut off abruptly in the middle of a sentence. I'm guessing this was a mistake, but if you're able to flesh this out a bit further it would be appreciated. Lumberjane Lilly (talk) 17:44, 16 December 2020 (UTC)[reply]