Talk:Amino acid/GA2
GA Review
[edit]Article (edit | visual edit | history) · Article talk (edit | history) · Watch
Start the review today--Stone (talk) 13:43, 10 November 2008 (UTC)
The article is quite good, but needs a few things here and there.
For my understanding: This article is only about the alpha-amino acids or about all amino acids or only those used in biochemistry? This has to be stated in the lead.
- Changed to state that this is about AA in general, but that they are particularly important in biochemistry.
- The beta-amino acids and the gamma-amino acids should be inclueded in a way that it reflects this. Now the article mentiones them only a few times although they are important as well. Beta-alanine which is part in Pantothenic acid and therfor also part of Coenzyme A is a key compound in biochemistry.
- Discussion of beta and gamma nomenclature added to general structure section, beta-alanine added to non-standard amino acids section
- The beta-amino acids and the gamma-amino acids should be inclueded in a way that it reflects this. Now the article mentiones them only a few times although they are important as well. Beta-alanine which is part in Pantothenic acid and therfor also part of Coenzyme A is a key compound in biochemistry.
- Changed to state that this is about AA in general, but that they are particularly important in biochemistry.
the R in the lead is hard to get if you do not have a image to but it, so why not exchange the first with the third (AminoAcidball.svg) image?
- Good idea! Images swapped.
The non protein function section includes section about the Murchison meteorite. This implies that the found amino acids had non protein function. This section belongs somewhere elese in the article a occurence section might be a good thing.
- Reworded to state that this is of relevance to the origin of life and moved to own section at the end.
In the lead the α–carbon is used while later on Cα is used.
- Standardised to α–carbon
Cα, is a chiral central carbon atom (with the exception of glycine) to which the two termini and the R-group are attached in General structure and Most amino acids can exist in either of two optical isomers. 'Isomerism are somwhat contradictive. Is most meaning all but one and what if I say 2-Aminoisobutyric acid which is not chiral but a alpha-amino acid.
- Reworded.
For R and S and cystein it would be better if it is mentioned that the counting is changed because sulfur of cystein being heavier than nitrogen, carbon and oxygen used for determining if a molecule is R or S.
- Added.
In Non-protein functions the alpha-amino acids which are used as toxines against others like canavanine and azetidin-2-carbonsäure should be mentioned.
- Added canavanine and mimosine.
Zwitterions belongs more into the structure section than the reactions section.
- Moved
The transamination, the urea cycle, and the biosynthesis of aminoacids should be mentioned in the reactions section.
Now mentioned in the metabolism section.A little bit short still. And it is not so easy to get where all the amino acids we eat and we are composed of come from.
Nonstandard amino acids there means only the ones which are used by biochemistry?
- Merged with biochemistry section
- Than you need a Other amino acids section!
- Applications in biodegradable plastics and chiral synthesis now separate sections.
- Than you need a Other amino acids section!
- Merged with biochemistry section
The headline Uses in technology only lists medicine and food additives applications which are not so technical applications. This subsection needs an extansion to pros. There mut be other uses of AA in techics and chemistry. The Chiral pool synthesis is one which comes to my mind and utalizes the chiral properties of natural chiral AA for the synthesis of substances.
- Added to industry section.
The Image:Schoellkopf-Hartwig.png and the Image:Strecker Amino Acid Synthesis Scheme.png show that chemist are also able to produce amino acids. A chemistry section would be really nice. GA means that everything relevant is mentioned.
- Added.
Caprolactam a lactam of a epsilon-amino acid is a key compound in the Nylon-6 production (Nylon-6-6 is not made of amino acids)
- Unfortunately, this isn't an amino acid, so doesn't belong in this article.
- But Aminocaproic acid is one.--Stone (talk) 21:40, 17 November 2008 (UTC)
- Unfortunately, this isn't an amino acid, so doesn't belong in this article.
Might add more tonight--Stone (talk) 14:37, 10 November 2008 (UTC) Might add even more soon.--Stone (talk) 22:30, 12 November 2008 (UTC)
Comment: After doing some minor copyediting, I noticed two relevant omissions:
- There is no mention of dihedral angles, the sum of which (to my understanding) gives rise to secondary and tertiary structure. It would seem appropriate to include the image here or here to convey the concept of phi, psi and omega angles within amino acids.
- As a corollary to the above point, perhaps it would be worth mentioning Anfinsen's dogma, that the amino acid sequence of a protein's primary structure determines its final conformation? Emw2012 (talk) 21:35, 15 November 2008 (UTC)
- I don't think either is particularly relevant, protein structure is covered in its own article and summarised in the protein article, this article only deals with amino acids. Tim Vickers (talk) 00:08, 16 November 2008 (UTC)
- It is well written. - Pass
- It is factually accurate and verifiable - Pass
- It is broad in its coverage - Pass
- It follows the neutral point of view policy - Pass
- It is stable - Pass
- It contains images, where possible, to illustrate the topic - Pass
- The only thing is that the beta and gamma AA have a little bit small part in the article and have no image of their own. A little section with its own heading would be very nice. Is this too much? If yes than I will pass it tomorrow.--Stone (talk) 21:34, 17 November 2008 (UTC)
- I've added an image comparing alpha and beta alanine to the non-standard AA section. Tim Vickers (talk) 21:45, 17 November 2008 (UTC)
Now its GA--Stone (talk) 14:09, 18 November 2008 (UTC)