Talk:Acetate-CoA ligase (ADP-forming)

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How can this reaction be adp-forming? There is not enough free energy to overcome the binding energy of the forming thioester. It is necessary to release an AMP and pyrophosphate, similar to the activation of all other monocarboxylated acids (e.g. palmitate). See also the article " Acetyl-CoA-Synthetase"! —Preceding unsigned comment added by 92.252.41.64 (talk) 15:08, 19 October 2008 (UTC)[reply]