Talk:ATP synthase delta/OSCP subunit

Merging with ATP50

These pages seem very similar. Probably because ATP50 is the gene that encodes the ATP synthase delta subunit. These should be combined into one more detailed article, individually they make weak articles. Aqua112233 (talk) 13:13, 19 February 2011 (UTC)

ATP5O is the gene that encodes this delta subunit in humans, many mammals and some others (25 genes, about 20 species). But, the article only discusses the human gene.

The OSCP delta subunit is encoded by a whole slew of genes, e.g. Gene ID: 8814052 (Thal_0559), from a variety of other non-mammalian organisms. The enzyme is EC 3.6.3.14 for the human gene. Many of the non-human organisms have no enzyme class listed. One that does is Gene ID: 8702415 ATPH for the organism Xanthomonas albilineans and it is EC 3.6.3.14. The OSCP designation applies to some 1361 genes listed in entrez Gene.

The article title, "ATP synthase delta subunit" refers to some 3351 genes in the same database. Many of these are mitochondrial, as is ATP5O, "ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [Homo sapiens]" from NCBI. But there are two different delta subunits as the article indicates. The other delta subunit is EC 3.6.1.14, which is also mitochondrial. So it depends on what the creators and editors would like to do. Having all of the ATP5Os in one article is reasonable. Including them in ATP synthase delta subunit is also reasonable but may eventually result in a split off of the ATP5Os. This article could be expanded with sections for each of the above, while keeping the ATP5O separate for primarily the human gene, and subsequent comparative genetics, especially for the medicine readers. The merge suggestion has been here since February 2011 with only our two opinions offered.

It is not true that the ATP5O gene encodes all the "ATP synthase delta subunit" genes, as indicated above. I agree with Aqua112233 that the two articles are weak. So, I vote for keeping them separate and improving both as indicated above. Marshallsumter (talk) 21:22, 10 July 2011 (UTC)

References

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