Talk:3C-like protease

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Update - new data on SARS-CoV-2 main protease function

Theres new data published on cleavage of cellular proteins as well as viral proteins by SARS-CoV-2 main protease - including PNN, PAICS and GOLGA3. The reference is ^[1]. I would add this, but I am an author on the paper so have a conflict of interest. --Edemmott (talk) 15:16, 24 September 2021 (UTC)[reply]

References

^ Meyer, Bjoern; Chiaravalli, Jeanne; Gellenoncourt, Stacy; Brownridge, Philip; Bryne, Dominic P.; Daly, Leonard A.; Grauslys, Arturas; Walter, Marius; Agou, Fabrice; Chakrabarti, Lisa A.; Craik, Charles S.; Eyers, Claire E.; Eyers, Patrick A.; Gambin, Yann; Jones, Andrew R.; Sierecki, Emma; Verdin, Eric; Vignuzzi, Marco; Emmott, Edward (December 2021). "Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential". Nature Communications. 12 (1): 5553. doi:10.1038/s41467-021-25796-w.

Graphic

The article’s current primary graphic is not a normal wild-type representation of a coronavirus’ nor SARS-CoV’s main protease. The main protease is not an oktamer. The image shown was the result of a single laboratory experiment in 2009. This graphic should be changed. Ricksher (talk) 08:36, 13 July 2020 (UTC)[reply]

Good point. The graphic was changed to a dimer. --Guest2625 (talk) 11:33, 13 July 2020 (UTC)[reply]

A Commons file used on this page or its Wikidata item has been nominated for deletion

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PF-07321332 structure.png

Participate in the deletion discussion at the nomination page. —Community Tech bot (talk) 14:38, 15 July 2021 (UTC)[reply]

Copyright problem removed

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[1] Meyer, Bjoern; Chiaravalli, Jeanne; Gellenoncourt, Stacy; Brownridge, Philip; Bryne, Dominic P.; Daly, Leonard A.; Grauslys, Arturas; Walter, Marius; Agou, Fabrice; Chakrabarti, Lisa A.; Craik, Charles S.; Eyers, Claire E.; Eyers, Patrick A.; Gambin, Yann; Jones, Andrew R.; Sierecki, Emma; Verdin, Eric; Vignuzzi, Marco; Emmott, Edward (December 2021). "Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential". Nature Communications. 12 (1): 5553. doi:10.1038/s41467-021-25796-w.

[1]