Talk:3,4-Dimethoxyphenethylamine

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unsourced stuff

moved here per PRESERVE. But BURDEN pls don't restore w/out finding reliable secondary sources, checking against them, and citing them.

from "chemistry section" 3,4-Dimethoxybenzaldehyde is reacted with nitromethane in the presence of ammonium acetate/acetic acid to give the corresponding β-nitrostyrene, which is then reduced with LiAlH₄ to give 3,4-dimethoxyphenethylamine.

Derivatives

DMPEA is used as a precursor in the synthesis of a plethora of pharmaceutical drugs, including:

Bisobrin, Bometolol, Buquiterine, Denopamine, Dobutamine, Dopamine, Dopexamine, Dramedilol, Drotaverine, Ecastolol, Falipamil, Gallopamil, Methopholine, Mixidine, Mefeclorazine, Nuciferine, papaverine, Tetrabenazine, Tiapamil, trimethoquinol, Veradoline, verapamil.

DMPEA was recently used to prepare Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists.^[1]

References

^ Crestey, François; Jensen, Anders A.; Borch, Morten; Andreasen, Jesper Tobias; Andersen, Jacob; Balle, Thomas; Kristensen, Jesper Langgaard (2013). "Design, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists". Journal of Medicinal Chemistry. 56 (23): 9673–9682. doi:10.1021/jm4013592. ISSN 0022-2623.

-- 20:07, 30 April 2017 (UTC)

[CresteyJensen2013-1] Crestey, François; Jensen, Anders A.; Borch, Morten; Andreasen, Jesper Tobias; Andersen, Jacob; Balle, Thomas; Kristensen, Jesper Langgaard (2013). "Design, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists". Journal of Medicinal Chemistry. 56 (23): 9673–9682. doi:10.1021/jm4013592. ISSN 0022-2623.

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