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Does the letter after the 25 mean or stand for something, or is each compound just assigned an arbitrary letter from the alphabet in order? Is there a difference between 25B- compounds and 25C- compounds, and if so, what? Is it pronounced "twenty-five NB" or "two five NB"? Widsith (talk) 14:34, 16 May 2018 (UTC)[reply]
The letter after the 25 stands for the substituent at the phenethyl 4-position, most of them correspond to the first letter of the name e.g. B = bromo, C = chloro, I = iodo, E = ethyl etc. However there are some oddballs resulting from the idiosyncratic naming of the 2C-x parent compounds, so D = methyl and T7 = propylthio for instance. The 25 is pronounced "two five" as it refers to the 2 and 5 methoxy groups on the phenyl ring (though most people would probably understand if you said "twenty five B" that you meant 25B-NBOMe). The NB stands for N Benzyl then at the end is the benzyl substituent which is at the 2-position by default, so N-(2-methoxybenzyl) becomes NBOMe, N-(2-fluorobenzyl) becomes NBF etc. If the benzyl substituent is not at the 2-position then an extra number is added, e.g. N-(3-methoxybenzyl) is NB3OMe. Meodipt (talk) 07:45, 27 April 2019 (UTC)[reply]
