Talk:14-Cinnamoyloxycodeinone

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I have taken the potency values for each homologue given in the Lenz book - can someone make a table of them please:

14-ester x Morphine

H 0.3 COCH3 4 COC2H5 20 COC3H7-n 30 COCH1CH=CHz 30 COC4H9-n 40 COC5H11-n 50 COC6HIJ-n 60 COC7H15-n 5 COC9H17=n 1 COC11HI9-n 0.03 CO(CH2)C6H5 50 CO(CH2)2C6H5 115 COCH=CH-C6H5 175±75 COCH=CH-CH3 31 — Preceding unsigned comment added by 213.106.56.145 (talk) 13:10, 5 November 2012 (UTC)[reply]

Activity or structure in error - 7-8 double-bond not present.

The Reference given gives the QSAR for oxycodone esters (the 7-8 double bond reduced). The papers title alludes to hydrocodeinone esters but all of the examples with high potency are the reduced derivatives. A good explaination of this is given in the book 'Opiates' 1986 Academic Press (ISBN 0-12-443830-X)

by George R. Lenz, Suzanne M. Evans, D. Eric Walters, Anton J. Hopfinger on pages 97-99.  —Preceding unsigned comment added by 86.30.243.179 (talk) 11:53, 17 May 2011 (UTC)[reply]