Tabernaemontana corymbosa

Tabernaemontana corymbosa
Conservation status
	; Least Concern (IUCN 3.1)
Scientific classification
Kingdom:	Plantae
Clade:	Tracheophytes
Clade:	Angiosperms
Clade:	Eudicots
Clade:	Asterids
Order:	Gentianales
Family:	Apocynaceae
Genus:	Tabernaemontana
Species:	T. corymbosa
Binomial name
	Tabernaemontana corymbosa; Roxb. ex Wall.
Synonyms
	List Ervatamia corymbosa (Roxb. ex Wall.) King & Gamble ; Pagiantha corymbosa (Roxb. ex Wall.) Markgr. ; Ervatamia baviensis (Pit.) Pichon ; Ervatamia chinensis (Merr.) Tsiang ; Ervatamia continentalis Tsiang ; Ervatamia hirta (Hook.f.) King & Gamble ; Ervatamia inaequalifolia (Lütjeh. & Ooststr.) Pichon ; Ervatamia jasminiflora Ridl. ; Ervatamia kwangsiensis Tsiang ; Ervatamia kweichowensis Tsiang ; Ervatamia laotica (Pit.) Pichon ; Ervatamia longopedicellata Lý ; Ervatamia pauciflora Ridl. ; Ervatamia phuongii Lý ; Ervatamia tenuiflora Tsiang ; Ervatamia yunnanensis Tsiang ; Pagiantha peninsularis Kerr ; Tabernaemontana baviensis Pit. ; Tabernaemontana carinata Lütjeh. & Ooststr. ; Tabernaemontana chinensis Merr. ; Tabernaemontana continentalis (Tsiang) P.T.Li ; Tabernaemontana cymulosa Miq. ; Tabernaemontana hirta Hook.f. ; Tabernaemontana inaequalifolia Lütjeh. & Ooststr. ; Tabernaemontana kwangsiensis (Tsiang) P.T.Li ; Tabernaemontana kweichowensis (Tsiang) P.T.Li ; Tabernaemontana laotica Pit. ; Tabernaemontana peninsularis (Kerr) P.T.Li ; Tabernaemontana pubituba Merr. ; Tabernaemontana sumatrana (Miq.) Hallier f. ; Tabernaemontana tsiangiana P.T.Li ; Tabernaemontana yunnanensis (Tsiang) P.T.Li ; Pseudixora sumatrana Miq. ; Randia sumatrana (Miq.) Miq. ;

Tabernaemontana corymbosa is a species of plant in the family Apocynaceae. It is native to Brunei, China, Indonesia, Laos, Malaysia, Myanmar, Singapore, Thailand, and Vietnam. Glossy green leaves and faintly sweet scented flower. Flowers continuously all year. Frost tolerant. Grows to about 2 metres. Likes full sun to part shade. A number of cultivars are available.

Chemical composition

Multiple compounds of different classes such as Iboga alkaloids and Bisindole alkaloids have been isolated from this plant. Alkaloids such as conodusine A-E, conolodinines A-D, conophylline, conophyllinine and taberyunines A-I are present in which many shows antiproliferative and cytotoxic actions.^[3]^[4]^[5]^[6]

References

^ Oldfield, S. (2023). "Tabernaemontana corymbosa". IUCN Red List of Threatened Species. 2023: e.T34504A212025220. Retrieved 28 February 2024.
^ "Tabernaemontana corymbosa". Plants of the World Online. Royal Botanic Gardens, Kew. Retrieved 28 February 2024.
^ Zhang Y, Ding X, Yuan YX, Guo LL, Hao XJ (May 2020). "Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification". Journal of Natural Products. 83 (5): 1432–1439. doi:10.1021/acs.jnatprod.9b00856. PMID 32356659. S2CID 218474047.
^ Sim DS, Navanesan S, Sim KS, Gurusamy S, Lim SH, Low YY, Kam TS (April 2019). "Conolodinines A-D, Aspidosperma- Aspidosperma Bisindole Alkaloids with Antiproliferative Activity from Tabernaemontana corymbosa". Journal of Natural Products. 82 (4): 850–858. doi:10.1021/acs.jnatprod.8b00919. PMID 30869890. S2CID 78093751.
^ Zhang BJ, Lu JS, Bao MF, Zhong XH, Ni L, Wu J, Cai XH (August 2018). "Bisindole alkaloids from Tabernaemontana corymbosa". Phytochemistry. 152: 125–133. doi:10.1016/j.phytochem.2018.04.020. PMID 29758521. S2CID 21727496.
^ Nge CE, Chong KW, Thomas NF, Lim SH, Low YY, Kam TS (May 2016). "Ibogan, Aspidosperman, Vincamine, and Bisindole Alkaloids from a Malayan Tabernaemontana corymbosa: Iboga Alkaloids with C-20α Substitution". Journal of Natural Products. 79 (5): 1388–99. doi:10.1021/acs.jnatprod.6b00129. PMID 27077800.

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[IUCN-1] Oldfield, S. (2023). "Tabernaemontana corymbosa". IUCN Red List of Threatened Species. 2023: e.T34504A212025220. Retrieved 28 February 2024.

[POWO-2] "Tabernaemontana corymbosa". Plants of the World Online. Royal Botanic Gardens, Kew. Retrieved 28 February 2024.

[pmid32356659-3] Zhang Y, Ding X, Yuan YX, Guo LL, Hao XJ (May 2020). "Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification". Journal of Natural Products. 83 (5): 1432–1439. doi:10.1021/acs.jnatprod.9b00856. PMID 32356659. S2CID 218474047.

[pmid30869890-4] Sim DS, Navanesan S, Sim KS, Gurusamy S, Lim SH, Low YY, Kam TS (April 2019). "Conolodinines A-D, Aspidosperma- Aspidosperma Bisindole Alkaloids with Antiproliferative Activity from Tabernaemontana corymbosa". Journal of Natural Products. 82 (4): 850–858. doi:10.1021/acs.jnatprod.8b00919. PMID 30869890. S2CID 78093751.

[pmid29758521-5] Zhang BJ, Lu JS, Bao MF, Zhong XH, Ni L, Wu J, Cai XH (August 2018). "Bisindole alkaloids from Tabernaemontana corymbosa". Phytochemistry. 152: 125–133. doi:10.1016/j.phytochem.2018.04.020. PMID 29758521. S2CID 21727496.

[pmid27077800-6] Nge CE, Chong KW, Thomas NF, Lim SH, Low YY, Kam TS (May 2016). "Ibogan, Aspidosperman, Vincamine, and Bisindole Alkaloids from a Malayan Tabernaemontana corymbosa: Iboga Alkaloids with C-20α Substitution". Journal of Natural Products. 79 (5): 1388–99. doi:10.1021/acs.jnatprod.6b00129. PMID 27077800.

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Tabernaemontana corymbosa

Conservation status
Least Concern (IUCN 3.1)^[1]
Scientific classification
Kingdom:	Plantae
Clade:	Tracheophytes
Clade:	Angiosperms
Clade:	Eudicots
Clade:	Asterids
Order:	Gentianales
Family:	Apocynaceae
Genus:	Tabernaemontana
Species:	T. corymbosa
Binomial name
*Tabernaemontana corymbosa* Roxb. ex Wall.^[2]
Synonyms
List Ervatamia corymbosa (Roxb. ex Wall.) King & Gamble Pagiantha corymbosa (Roxb. ex Wall.) Markgr. Ervatamia baviensis (Pit.) Pichon Ervatamia chinensis (Merr.) Tsiang Ervatamia continentalis Tsiang Ervatamia hirta (Hook.f.) King & Gamble Ervatamia inaequalifolia (Lütjeh. & Ooststr.) Pichon Ervatamia jasminiflora Ridl. Ervatamia kwangsiensis Tsiang Ervatamia kweichowensis Tsiang Ervatamia laotica (Pit.) Pichon Ervatamia longopedicellata Lý Ervatamia pauciflora Ridl. Ervatamia phuongii Lý Ervatamia tenuiflora Tsiang Ervatamia yunnanensis Tsiang Pagiantha peninsularis Kerr Tabernaemontana baviensis Pit. Tabernaemontana carinata Lütjeh. & Ooststr. Tabernaemontana chinensis Merr. Tabernaemontana continentalis (Tsiang) P.T.Li Tabernaemontana cymulosa Miq. Tabernaemontana hirta Hook.f. Tabernaemontana inaequalifolia Lütjeh. & Ooststr. Tabernaemontana kwangsiensis (Tsiang) P.T.Li Tabernaemontana kweichowensis (Tsiang) P.T.Li Tabernaemontana laotica Pit. Tabernaemontana peninsularis (Kerr) P.T.Li Tabernaemontana pubituba Merr. Tabernaemontana sumatrana (Miq.) Hallier f. Tabernaemontana tsiangiana P.T.Li Tabernaemontana yunnanensis (Tsiang) P.T.Li Pseudixora sumatrana Miq. Randia sumatrana (Miq.) Miq.