TXNL4A

TXNL4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PQN, 1QGV, 1SYX, 4BWQ, 4BWS, 4CDO, 3JCR
Identifiers
Aliases	TXNL4A, DIB1, DIM1, HsT161, SNRNP15, TXNL4, U5-15kD, BMKS, thioredoxin like 4A
External IDs	OMIM: 611595; MGI: 1351613; HomoloGene: 7150; GeneCards: TXNL4A; OMA:TXNL4A - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	80,033,949 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; amygdala; ; right testis; ; left testis; ; endothelial cell; ; anterior pituitary; ; C1 segment; ; prefrontal cortex; ; gingival epithelium; ; right frontal lobe;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	U5 snRNP; spliceosomal complex; nucleoplasm; nucleus; cytosol; nuclear membrane; U4/U6 x U5 tri-snRNP complex; U2-type precatalytic spliceosome;
Biological process	RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; cell cycle; mRNA processing; spliceosomal complex assembly; cell division; RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
	10907
	27366
	ENSG00000141759
	ENSMUSG00000057130
	P83876
	P83877
	NM_001303471; NM_001305557; NM_001305563; NM_001305564; NM_006701
	NM_001038608; NM_001042408; NM_001042409; NM_025299; NM_178604
	NP_001290400; NP_001292486; NP_001292492; NP_001292493; NP_006692
NP_001033697; NP_001035867; NP_079575; NP_848719; NP_001371102;
	NP_001371103; NP_001371104; NP_001371105; NP_001371106
	Wikidata
View/Edit Human	View/Edit Mouse

Thioredoxin-like protein 4A is a protein that is encoded by the TXNL4A gene in humans.^[4]^[5]

Interactions

TXNL4A has been shown to interact with PQBP1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141759 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang YZ, Gould KL, Dunbrack RL JR, Cheng H, Roder H, Golemis EA (October 2000). "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily". Physiol Genomics. 1 (3): 109–18. doi:10.1152/physiolgenomics.1999.1.3.109. PMID 11015569. S2CID 16086223.
^ "Entrez Gene: TXNL4A thioredoxin-like 4A".
^ Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (October 2000). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1". Gene. 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.

Reuter K, Nottrott S, Fabrizio P, Lührmann R, Ficner R (2000). "Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein". J. Mol. Biol. 294 (2): 515–25. doi:10.1006/jmbi.1999.3258. PMID 10610776.
Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (2001). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1". Gene. 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.
Zhang YZ, Cheng H, Gould KL, Golemis EA, Roder H (2003). "Structure, stability, and function of hDim1 investigated by NMR, circular dichroism, and mutational analysis". Biochemistry. 42 (32): 9609–18. doi:10.1021/bi034486i. PMID 12911302.
Laggerbauer B, Liu S, Makarov E, Vornlocher HP, Makarova O, Ingelfinger D, Achsel T, Lührmann R (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation" (PDF). RNA. 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Jin T, Guo F, Wang Y, Zhang YZ (2007). "Identification of human dim1 as a peptidase with autocleavage activity". Chemical Biology & Drug Design. 68 (5): 266–72. doi:10.1111/j.1747-0285.2006.00447.x. PMID 17177886. S2CID 13020526.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141759 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11015569-4] Zhang YZ, Gould KL, Dunbrack RL JR, Cheng H, Roder H, Golemis EA (October 2000). "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily". Physiol Genomics. 1 (3): 109–18. doi:10.1152/physiolgenomics.1999.1.3.109. PMID 11015569. S2CID 16086223.

[entrez-5] "Entrez Gene: TXNL4A thioredoxin-like 4A".

[pmid11054566-6] Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (October 2000). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1". Gene. 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.

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[2]

[3]

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[5]

[6]

Interactions

References

Further reading