TTFB (chemical)

TTFB
Identifiers
CAS Number	2338-29-6 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:1744;
ChEMBL	ChEMBL4572335;
ChemSpider	67893;
KEGG	C11322;
PubChem CID	75357;
CompTox Dashboard (EPA)	DTXSID30177936 ;
	InChI InChI=1S/C8HCl4F3N2/c9-1-2(10)4(12)6-5(3(1)11)16-7(17-6)8(13,14)15/h(H,16,17) Key: QLKDMIUEWFNEPV-UHFFFAOYSA-N;
	SMILES C12=C(C(=C(C(=C1Cl)Cl)Cl)Cl)N=C(N2)C(F)(F)F;
Properties
Chemical formula	C8HCl4F3N2
Molar mass	323.91 g·mol−1
Hazards
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	23 mg/kg (mice, intraperitoneal)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

TTFB (4,5,6,7-Tetrachloro-2-trifluoromethylbenzimidazole) is a halogenated benzimidazole derivative that acts as an uncoupling agent.^[2]

References

^ Ilivicky, J; Casida, JE (June 1969). "Uncoupling action of 2,4-dinitrophenols, 2-trifluoromethylbenzimidazoles and certain other pesticide chemicals upon mitochondria from different sources and its relation to toxicity". Biochemical Pharmacology. 18 (6): 1389–401. doi:10.1016/0006-2952(69)90252-4. PMID 5799112.
^ Beechey, RB (January 1966). "The uncoupling of respiratory-chain phosphorylation by 4,5,6,7-tetrachloro-2-trifluoromethylbenzimidazole". The Biochemical Journal. 98 (1): 284–9. doi:10.1042/bj0980284. PMC 1264827. PMID 4223043.

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