TTBK1

TTBK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BTJ, 4BTK, 4BTM, 4NFM, 4NFN
Identifiers
Aliases	TTBK1, BDTK, tau tubulin kinase 1
External IDs	MGI: 2147036; HomoloGene: 50342; GeneCards: TTBK1; OMA:TTBK1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,288,258 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,798,601 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; prefrontal cortex; ; postcentral gyrus; ; right frontal lobe; ; right hemisphere of cerebellum; ; superior frontal gyrus; ; anterior cingulate cortex; ; entorhinal cortex; ; Brodmann area 9; ; amygdala;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; seminiferous tubule; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; Rostral migratory stream; ; primary motor cortex; ; cingulate gyrus; ; spermatid; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; ATP binding; kinase activity; tau protein binding; tau-protein kinase activity;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol; microtubule associated complex; soma; perinuclear region of cytoplasm;
Biological process	protein phosphorylation; peptidyl-serine phosphorylation; substantia nigra development; phosphorylation; regulation of cell shape; learning or memory; positive regulation of gene expression; negative regulation of gene expression; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; negative regulation of protein binding; positive regulation of protein polymerization; positive regulation of astrocyte activation; positive regulation of microglial cell activation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of cysteine-type endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	84630
	106763
	ENSG00000146216
	ENSMUSG00000015599
	Q5TCY1
	Q6PCN3
	NM_032538
	NM_001162864; NM_175351
	NP_115927
	NP_001156336
	Wikidata
View/Edit Human	View/Edit Mouse

Tau tubulin kinase 1 is a protein that in humans is encoded by the TTBK1 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146216 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015599 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Tau tubulin kinase 1". Retrieved 2017-03-23.

Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T (2008). "Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1". J. Neurosci. 28 (53): 14511–21. doi:10.1523/JNEUROSCI.3417-08.2008. PMC 6671237. PMID 19118186.
Vázquez-Higuera JL, Martínez-García A, Sánchez-Juan P, Rodríguez-Rodríguez E, Mateo I, Pozueta A, Frank A, Valdivieso F, Berciano J, Bullido MJ, Combarros O (2011). "Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort". Neurobiol. Aging. 32 (3): 550.e5–9. doi:10.1016/j.neurobiolaging.2009.12.021. PMID 20096481. S2CID 5587797.
Vázquez-Higuera JL, Martínez-García A, Sánchez-Juan P, Rodríguez-Rodríguez E, Mateo I, Pozueta A, Frank A, Valdivieso F, Berciano J, Bullido MJ, Combarros O (2011). "Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort". Neurobiol. Aging. 32 (3): 550.e5–9. doi:10.1016/j.neurobiolaging.2009.12.021. PMID 20096481. S2CID 5587797.
Yu NN, Yu JT, Xiao JT, Zhang HW, Lu RC, Jiang H, Xing ZH, Tan L (2011). "Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese". Neurosci. Lett. 491 (1): 83–6. doi:10.1016/j.neulet.2011.01.011. PMID 21219968. S2CID 6421145.
Lund H, Cowburn RF, Gustafsson E, Strömberg K, Svensson A, Dahllund L, Malinowsky D, Sunnemark D (2013). "Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain". Brain Pathol. 23 (4): 378–89. doi:10.1111/bpa.12001. PMC 8029021. PMID 23088643. S2CID 30089308.
Kiefer SE, Chang CJ, Kimura SR, Gao M, Xie D, Zhang Y, Zhang G, Gill MB, Mastalerz H, Thompson LA, Cacace AM, Sheriff S (2014). "The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor". Acta Crystallogr F. 70 (Pt 2): 173–81. doi:10.1107/S2053230X14000144. PMC 3936456. PMID 24637750.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146216 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015599 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Tau tubulin kinase 1". Retrieved 2017-03-23.

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References

Further reading