TSQ

TSQ
Names
	Preferred IUPAC name N-(6-Methoxyquinolin-8-yl)-4-methylbenzene-1-sulfonamide
Identifiers
CAS Number	109628-27-5 ;
3D model (JSmol)	Interactive image;
ChemSpider	115530 ;
PubChem CID	130606;
UNII	7SWW052N6R ;
CompTox Dashboard (EPA)	DTXSID00148996 ;
	InChI InChI=1S/C17H16N2O3S/c1-12-5-7-15(8-6-12)23(20,21)19-16-11-14(22-2)10-13-4-3-9-18-17(13)16/h3-11,19H,1-2H3 Key: HKRNYOZJJMFDBV-UHFFFAOYSA-N ; InChI=1/C17H16N2O3S/c1-12-5-7-15(8-6-12)23(20,21)19-16-11-14(22-2)10-13-4-3-9-18-17(13)16/h3-11,19H,1-2H3 Key: HKRNYOZJJMFDBV-UHFFFAOYAJ;
	SMILES O=S(=O)(c1ccc(cc1)C)Nc2cc(OC)cc3cccnc23;
Properties
Chemical formula	C17H16N2O3S
Molar mass	328.39 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

6-Methoxy-(8-p-toluenesulfonamido)quinoline (TSQ) is one of the most efficient fluorescent stains for zinc(II). It was introduced by Soviet biochemists Toroptsev and Eshchenko in the early 1970s. The popularity of TSQ as physiological stain rose after seminal works by Christopher Frederickson two decades later.^[1] TSQ forms a 2:1 (ligand-metal) complex with zinc and emits blue light upon excitation at 365 nanometers. TSQ has been extensively applied for determination of extracellular or intracellular levels of Zn²⁺ in biological systems, also to study Zn²⁺ in mossy fibers of the hippocampus.

References

^ See for example: Suh S W; Jensen K B; Jensen M S; Silva D S; et al. (2000). "Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains". Brain Research. 852 (2): 274–278. doi:10.1016/S0006-8993(99)02096-X. PMID 10678753. S2CID 20822326.

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[1] See for example: Suh S W; Jensen K B; Jensen M S; Silva D S; et al. (2000). "Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains". Brain Research. 852 (2): 274–278. doi:10.1016/S0006-8993(99)02096-X. PMID 10678753. S2CID 20822326.

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