TRNA (guanine26-N2)-dimethyltransferase
| TRNA (guanine26-N2)-dimethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.216 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
TRNA (guanine26-N2)-dimethyltransferase (EC 2.1.1.216, Trm1p, TRM1, tRNA (m22G26)dimethyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine26-N2)-dimethyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 2 S-adenosyl-L-methionine + guanine26 in tRNA 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions.
References
[edit]- ^ Constantinesco F, Motorin Y, Grosjean H (August 1999). "Characterisation and enzymatic properties of tRNA(guanine 26, N (2), N (2))-dimethyltransferase (Trm1p) from Pyrococcus furiosus". Journal of Molecular Biology. 291 (2): 375–92. doi:10.1006/jmbi.1999.2976. PMID 10438627.
- ^ Constantinesco F, Benachenhou N, Motorin Y, Grosjean H (August 1998). "The tRNA(guanine-26,N2-N2) methyltransferase (Trm1) from the hyperthermophilic archaeon Pyrococcus furiosus: cloning, sequencing of the gene and its expression in Escherichia coli". Nucleic Acids Research. 26 (16): 3753–61. doi:10.1093/nar/26.16.3753. PMC 147764. PMID 9685492.
- ^ Liu J, Liu J, Stråby KB (November 1998). "Point and deletion mutations eliminate one or both methyl group transfers catalysed by the yeast TRM1 encoded tRNA (m22G26)dimethyltransferase". Nucleic Acids Research. 26 (22): 5102–8. doi:10.1093/nar/26.22.5102. PMC 147968. PMID 9801306.
- ^ Liu J, Zhou GQ, Stråby KB (January 1999). "Caenorhabditis elegans ZC376.5 encodes a tRNA (m2/2G(26))dimethyltransferance in which (246)arginine is important for the enzyme activity". Gene. 226 (1): 73–81. doi:10.1016/s0378-1119(98)00550-2. PMID 10048958.
External links
[edit]- TRNA+(guanine26-N2)-dimethyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
