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TRNA (adenine22-N1)-methyltransferase

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TRNA (adenine22-N1)-methyltransferase
Identifiers
EC no.2.1.1.217
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

TRNA (adenine22-N1)-methyltransferase (EC 2.1.1.217, TrmK, YqfN, Sp1610 (gene), tRNA: m1A22 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine22-N1)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine22 in tRNA S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA

The enzyme specifically methylates adenine22 in tRNA.

References

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  1. ^ Ta HM, Kim KK (March 2010). "Crystal structure of Streptococcus pneumoniae Sp1610, a putative tRNA methyltransferase, in complex with S-adenosyl-L-methionine". Protein Science. 19 (3): 617–24. doi:10.1002/pro.319. PMC 2866285. PMID 20052680.
  2. ^ Roovers M, Kaminska KH, Tkaczuk KL, Gigot D, Droogmans L, Bujnicki JM (June 2008). "The YqfN protein of Bacillus subtilis is the tRNA: m1A22 methyltransferase (TrmK)". Nucleic Acids Research. 36 (10): 3252–62. doi:10.1093/nar/gkn169. PMC 2425500. PMID 18420655.
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