TRIP4

TRIP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E5O
Identifiers
Aliases	TRIP4, ASC-1, ASC1, HsT17391, ZC2HC5, SMABF1, thyroid hormone receptor interactor 4, MDCDC
External IDs	OMIM: 604501; MGI: 1928469; HomoloGene: 9426; GeneCards: TRIP4; OMA:TRIP4 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,455,303 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,816,076 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; amniotic fluid; ; mucosa of transverse colon; ; jejunal mucosa; ; monocyte; ; gonad; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; ganglionic eminence; ; anterior pituitary;
	Top expressed in
	pineal gland; ; granulocyte; ; spermatocyte; ; left lobe of liver; ; zygote; ; spermatid; ; lumbar spinal ganglion; ; secondary oocyte; ; substantia nigra; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protease binding; transcription coactivator activity; zinc ion binding; estrogen receptor binding; protein binding; histone acetyltransferase binding; nuclear receptor binding; ubiquitin-like protein ligase binding; metal ion binding; protein kinase binding;
Cellular component	cytoplasm; cytosol; cytoskeleton; nucleus; nucleoplasm; microtubule organizing center; neuromuscular junction; nuclear body; activating signal cointegrator 1 complex; centrosome; protein-containing complex;
Biological process	positive regulation of transcription, DNA-templated; toxin transport; intracellular estrogen receptor signaling pathway; transcription, DNA-templated; regulation of transcription, DNA-templated; regulation of myoblast differentiation;
	Sources:Amigo / QuickGO
Orthologs
	9325
	56404
	ENSG00000103671
	ENSMUSG00000032386
	Q15650
	Q9QXN3
	NM_016213; NM_001321924
	NM_001170907; NM_019797; NM_001357872
	NP_001308853; NP_057297
	NP_001164378; NP_062771; NP_001344801
	Wikidata
View/Edit Human	View/Edit Mouse

Activating signal cointegrator 1 is a protein that in humans is encoded by the TRIP4 gene.^[5]^[6]

Interactions

TRIP4 has been shown to interact with Nuclear receptor coactivator 1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103671 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032386 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.
^ "Entrez Gene: TRIP4 thyroid hormone receptor interactor 4".
^ Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jung DJ, Sung HS, Goo YW, et al. (2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
Lee SK, Anzick SL, Choi JE, et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
Kim HJ, Yi JY, Sung HS, et al. (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103671 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032386 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7776974-5] Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.

[entrez-6] "Entrez Gene: TRIP4 thyroid hormone receptor interactor 4".

[pmid10454579-7] Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.

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Interactions

References

Further reading