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TMEM59

From Wikipedia, the free encyclopedia
TMEM59
Identifiers
AliasesTMEM59, C1orf8, HSPC001, DCF1, PRO195, UNQ169, transmembrane protein 59
External IDsOMIM: 617084; MGI: 1929278; HomoloGene: 3583; GeneCards: TMEM59; OMA:TMEM59 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_029565

RefSeq (protein)

NP_083841

Location (UCSC)Chr 1: 54.03 – 54.05 MbChr 4: 107.04 – 107.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene.[5][6]

TMEM59 is a membrane bound protein that is localized to the Golgi apparatus.[7] The precise function of TMEM59 is not known, however it has been demonstrated that expression of TMEM59 protein inhibits Golgi glycosylation of amyloid precursor protein (APP) and blocks APP cleavage by the α- and β-amyloid precursor protein secretases and therefore inhibits formation of the beta amyloid peptide that forms amyloid plaques in Alzheimer's disease.[7] Moreover, TMEM59 has been shown to potentiate wnt signaling by promoting formation of the wnt receptor signalosomes. Transmembrane interactions between TMEM59 and the wnt receptor Frizzled were found to drive receptor multimerization that leads to improved potency and efficacy of wnt signaling.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116209Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028618Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  6. ^ "Entrez Gene: TMEM59 transmembrane protein 59".
  7. ^ a b Ullrich S, Münch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF (July 2010). "The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein". The Journal of Biological Chemistry. 285 (27): 20664–74. doi:10.1074/jbc.M109.055608. PMC 2898310. PMID 20427278.
  8. ^ Gerlach JP, Jordens I, Tauriello DV, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJ, Egan DA, Maurice MM (April 2018). "TMEM59 potentiates Wnt signaling by promoting signalosome formation". Proceedings of the National Academy of Sciences of the United States of America. 115 (17): E3996–E4005. Bibcode:2018PNAS..115E3996G. doi:10.1073/pnas.1721321115. PMC 5924918. PMID 29632210.

Further reading

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