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Protein-coding gene in the species Homo sapiens
Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene .[ 5] [ 6]
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes . This gene is amplified and overexpressed in some ovarian cancers , and mutations in this gene can cause holoprosencephaly .[ 6]
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