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TESK2

From Wikipedia, the free encyclopedia
TESK2
Identifiers
AliasesTESK2, testis-specific kinase 2, testis associated actin remodelling kinase 2
External IDsOMIM: 604746; MGI: 2385204; HomoloGene: 5188; GeneCards: TESK2; OMA:TESK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007170
NM_001320800

NM_146151

RefSeq (protein)

NP_001307729
NP_009101

NP_666263

Location (UCSC)Chr 1: 45.34 – 45.49 MbChr 4: 116.58 – 116.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.[5][6]

Function

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This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meiotic stages and/or early stages of spermiogenesis.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000070759Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033985Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Røsok O, Pedeutour F, Ree AH, Aasheim HC (October 1999). "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis". Genomics. 61 (1): 44–54. doi:10.1006/geno.1999.5922. PMID 10512679.
  6. ^ a b "Entrez Gene: TESK2 testis-specific kinase 2".

Further reading

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