TESK2

TESK2
Identifiers
Aliases	TESK2, testis-specific kinase 2, testis associated actin remodelling kinase 2
External IDs	OMIM: 604746; MGI: 2385204; HomoloGene: 5188; GeneCards: TESK2; OMA:TESK2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.1 Start 45,343,883 bp End 45,491,163 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D1 Start 116,578,145 bp End 116,663,153 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue C1 segment secondary oocyte skin of abdomen jejunal mucosa skin of limb skin of leg duodenum skin of arm testicle Top expressed in granulocyte spermatid lobe of prostate sciatic nerve utricle seminiferous tubule vestibular membrane of cochlear duct left colon stria vascularis jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity nucleotide binding protein binding ATP binding metal ion binding kinase activity protein serine/threonine kinase activity signal transducer activity Cellular component nucleoplasm nucleus cytoplasm nuclear body Biological process protein phosphorylation peptidyl-tyrosine phosphorylation focal adhesion assembly actin cytoskeleton organization spermatogenesis phosphorylation intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10420 230661 Ensembl ENSG00000070759 ENSMUSG00000033985 UniProt Q96S53 Q8VCT9 RefSeq (mRNA) NM_007170 NM_001320800 NM_146151 RefSeq (protein) NP_001307729 NP_009101 NP_666263 Location (UCSC) Chr 1: 45.34 – 45.49 Mb Chr 4: 116.58 – 116.66 Mb PubMed search
Wikidata
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Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.

Function

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meiotic stages and/or early stages of spermiogenesis.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". The Journal of Biological Chemistry. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.
• Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (August 2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells". The Journal of Biological Chemistry. 276 (33): 31449–58. doi:10.1074/jbc.M102988200. PMID 11418599.