TBL3

TBL3
Identifiers
Aliases	TBL3, SAZD, UTP13, transducin beta like 3
External IDs	OMIM: 605915; MGI: 2384863; HomoloGene: 4711; GeneCards: TBL3; OMA:TBL3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	1,982,929 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,926,634 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; gastrocnemius muscle; ; apex of heart; ; muscle of thigh; ; skin of leg; ; skin of abdomen; ; ectocervix; ; mucosa of transverse colon; ; right lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; epiblast; ; spermatid; ; morula; ; embryo; ; embryo; ; ventricular zone; ; Ileal epithelium; ; maxillary prominence; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; snoRNA binding; RNA binding;
Cellular component	Pwp2p-containing subcomplex of 90S preribosome; small-subunit processome; nucleolus; nucleus; nucleoplasm;
Biological process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	10607
	213773
	ENSG00000183751
	ENSMUSG00000040688
	Q12788
	Q8C4J7
	NM_006453
	NM_145396
	NP_006444
	NP_663371
	Wikidata
View/Edit Human	View/Edit Mouse

Transducin beta-like protein 3 is a protein that in humans is encoded by the TBL3 gene.^[5]^[6]

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183751 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040688 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Weinstat-Saslow DL, Germino GG, Somlo S, Reeders ST (Mar 1994). "A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region". Genomics. 18 (3): 709–11. doi:10.1016/S0888-7543(05)80380-5. PMID 8307582.
^ ^a ^b "Entrez Gene: TBL3 transducin (beta)-like 3".

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183751 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040688 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8307582-5] Weinstat-Saslow DL, Germino GG, Somlo S, Reeders ST (Mar 1994). "A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region". Genomics. 18 (3): 709–11. doi:10.1016/S0888-7543(05)80380-5. PMID 8307582.

[entrez-6] "Entrez Gene: TBL3 transducin (beta)-like 3".

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References

Further reading