Suppressyn

ERVH48-1
Identifiers
Aliases	ERVH48-1, C21orf105, NDUFV3-AS1, endogenous retrovirus group 48 member 1, SUPYN
External IDs	GeneCards: ERVH48-1; OMA:ERVH48-1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	42,925,630 bp
RNA expression pattern
	Top expressed in
	placenta; ; sperm; ; gonad; ; decidua; ; bone marrow; ; ganglionic eminence; ; muscular system; ; muscle; ; muscle of thigh; ; body of pancreas;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	plasma membrane; extracellular region; extracellular space;
Biological process	syncytium formation;
	Sources:Amigo / QuickGO
Orthologs
	90625
	n/a
	ENSG00000233056
	n/a
	M5A8F1
	n/a
	NM_001308491
	n/a
	NP_001295420
	n/a
	Wikidata
View/Edit Human

Suppressyn (SUPYN) is a protein that in humans is encoded by the ERVH48-1 (endogenous retrovirus group 48 member 1) gene.

Suppressyn is expressed in embryos before implantation in the placenta, and also in the placenta. It was originally a gene for a viral coat protein that has become stabily integrated within the genomes of humans and other hominids. The function of this endogenous retrovirus protein is possibly to protect against infection by mammalian type D retroviruses.^[3] This is one of hundreds of similar genes.^[4]

Suppressyn binds to the receptor for syncytin-1 in the trophoblast.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000233056 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Frank JA, Singh M, Cullen HB, Kirou RA, Benkaddour-Boumzaouad M, Cortes JL, et al. (October 2022). "Evolution and antiviral activity of a human protein of retroviral origin". Science. 378 (6618): 422–428. doi:10.1126/science.abq7871. PMC 10542854. PMID 36302021.
^ Del Valle RP, McLaughlin RN (October 2022). "Stealing genes and facing consequences". Science. 378 (6618): 356–357. doi:10.1126/science.ade4942. PMID 36302006.
^ Sugimoto J, Schust DJ, Kinjo T, Aoki Y, Jinno Y, Kudo Y (December 2019). "Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation". Scientific Reports. 9 (1): 19502. Bibcode:2019NatSR...919502S. doi:10.1038/s41598-019-55933-x. PMC 6925194. PMID 31862915.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000233056 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Frank JA, Singh M, Cullen HB, Kirou RA, Benkaddour-Boumzaouad M, Cortes JL, et al. (October 2022). "Evolution and antiviral activity of a human protein of retroviral origin". Science. 378 (6618): 422–428. doi:10.1126/science.abq7871. PMC 10542854. PMID 36302021.

[4] Del Valle RP, McLaughlin RN (October 2022). "Stealing genes and facing consequences". Science. 378 (6618): 356–357. doi:10.1126/science.ade4942. PMID 36302006.

[5] Sugimoto J, Schust DJ, Kinjo T, Aoki Y, Jinno Y, Kudo Y (December 2019). "Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation". Scientific Reports. 9 (1): 19502. Bibcode:2019NatSR...919502S. doi:10.1038/s41598-019-55933-x. PMC 6925194. PMID 31862915.

[1]

[2]

[3]

[4]

[5]