Srp receptor alpha subunit

SRPRA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FH5, 2GO5, 5L3Q
Identifiers
Aliases	SRPRA, DP, Sralpha, SRPR, SRP receptor alpha subunit, SRP receptor subunit alpha
External IDs	OMIM: 182180; MGI: 1914648; HomoloGene: 2364; GeneCards: SRPRA; OMA:SRPRA - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	126,269,144 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	35,159,269 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; body of pancreas; ; beta cell; ; anterior pituitary; ; stromal cell of endometrium; ; corpus epididymis; ; body of stomach; ; cartilage tissue; ; right lobe of liver; ; minor salivary glands;
	Top expressed in
	parotid gland; ; lacrimal gland; ; submandibular gland; ; triceps brachii muscle; ; seminal vesicula; ; extensor digitorum longus muscle; ; sternocleidomastoid muscle; ; plantaris muscle; ; molar; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; signal recognition particle binding; GTP binding; GTPase activity; RNA binding;
Cellular component	signal recognition particle receptor complex; integral component of membrane; extracellular exosome; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	IRE1-mediated unfolded protein response; intracellular protein transport; cotranslational protein targeting to membrane; SRP-dependent cotranslational protein targeting to membrane; transport; protein targeting; protein targeting to ER;
	Sources:Amigo / QuickGO
Orthologs
	6734
	67398
	ENSG00000182934
	ENSMUSG00000032042
	P08240
	Q9DBG7
	NM_003139; NM_001177842
	NM_026130
	NP_001171313; NP_003130
	NP_080406
	Wikidata
View/Edit Human	View/Edit Mouse

SRP receptor alpha subunit is a protein that in humans is encoded by the SRPRA gene. ^[5]

Function

The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182934 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032042 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SRP receptor alpha subunit". Retrieved 2016-03-08.

Function

References

Further reading