Small nucleolar RNA snR54
| Small nucleolar RNA snR54 | |
|---|---|
 Predicted secondary structure and sequence conservation of snosnR54 | |
| Identifiers | |
| Symbol | snosnR54 |
| Rfam | RF00473 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; CD-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000593 |
| PDB structures | PDBe |
In molecular biology, snR54 is a non-coding RNA that is a member of the C/D class of snoRNA which contain the C box motif (UGAUGA) and D box motif (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. This snoRNA was first identified by a computational screen followed by experimental verification.[1] This RNA guides the 2'-O-methylation of 18S rRNA. In yeast this snoRNA is found to reside in an intron of the IMD4 gene.
Species distribution
[edit]This snoRNA has been identified in both yeasts and Drosophila melanogaster.[2]
References
[edit]- ^ Kiss T (April 2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell. 109 (2): 145–8. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400. S2CID 8968788.
- ^ Lowe TM, Eddy SR (February 1999). "A computational screen for methylation guide snoRNAs in yeast". Science. 283 (5405): 1168–71. Bibcode:1999Sci...283.1168L. doi:10.1126/science.283.5405.1168. PMID 10024243.
External links
[edit]- Page for Small nucleolar RNA snR54 at Rfam
- Entry for snR54 in the UMASS Amherst Yeast snoRNA database
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