Slp adaptor and csk interacting membrane protein

SCIMP
Identifiers
Aliases	SCIMP, C17orf87, UNQ5783, SLP adaptor and CSK interacting membrane protein
External IDs	OMIM: 614406; MGI: 3610314; HomoloGene: 52602; GeneCards: SCIMP; OMA:SCIMP - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	5,234,860 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,703,412 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; spleen; ; lymph node; ; appendix; ; blood; ; tonsil; ; gallbladder; ; smooth muscle tissue; ; duodenum;
	Top expressed in
	spleen; ; bone marrow; ; embryo; ; right kidney; ; thymus; ; ileum; ; jejunum; ; colon; ; adrenal gland; ; liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; uropod membrane; tetraspanin-enriched microdomain; membrane; leading edge membrane; immunological synapse;
Biological process	meiosis I; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	388325
	327957
	ENSG00000161929
	ENSMUSG00000057135
	Q6UWF3
	Q3UU41
	NM_001271842; NM_207103; NM_001319190
	NM_001045526
	NP_001258771; NP_001306119; NP_996986
	NP_001038991
	Wikidata
View/Edit Human	View/Edit Mouse

SLP adaptor and CSK interacting membrane protein is a protein that in humans is encoded by the SCIMP gene. ^[5]

Function

This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161929 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057135 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SLP adaptor and CSK interacting membrane protein". Retrieved 2018-05-24.

Function

References

Further reading