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Protein-coding gene in the species Homo sapiens
NEU2 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SNT , 1SO7 , 1VCU , 2F0Z , 2F10 , 2F11 , 2F12 , 2F13 , 2F24 , 2F25 , 2F26 , 2F27 , 2F28 , 2F29 , 4NC5 , 4NCS
Identifiers Aliases NEU2 External IDs OMIM : 605528 ; MGI : 1344417 ; HomoloGene : 3927 ; GeneCards : NEU2 ; OMA :NEU2 - orthologs Wikidata
Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene .[ 5] [ 6] [ 7]
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids . Expression studies in COS-7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000115488 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079434 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Monti E, Preti A, Rossi E, Ballabio A, Borsani G (Jun 1999). "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics . 57 (1): 137–143. doi :10.1006/geno.1999.5749 . PMID 10191093 . ^ Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E (Jan 2004). "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules" . J Biol Chem . 279 (5): 3169–3179. doi :10.1074/jbc.M308381200 PMID 14613940 . ^ a b "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)" .
Li CY, Yu Q, Ye ZQ, Sun Y, He Q, Li XM, Zhang W, Luo J, Gu X (2007). "A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir" . Cell Res . 17 (4): 357–362. doi :10.1038/cr.2007.27 PMID 17426694 . Chavas LM, Tringali C, Fusi P, Venerando B, Tettamanti G, Kato R, Monti E, Wakatsuki S (2005). "Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition" . J. Biol. Chem . 280 (1): 469–75. doi :10.1074/jbc.M411506200 PMID 15501818 . Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Hart ML, Saifuddin M, Uemura K, Bremer EG, Hooker B, Kawasaki T, Spear GT (2003). "High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1". AIDS Res. Hum. Retroviruses . 18 (17): 1311–1317. doi :10.1089/088922202320886352 . PMID 12487819 . Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Bassi MT, Sperandeo MP, Incerti B, Bulfone A, Pepe A, Surace EM, Gattuso C, De Grandi A, Buoninconti A (2000). "SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family". Genomics . 62 (2): 297–303. doi :10.1006/geno.1999.5978 . PMID 10610726 . Monti E, Preti A, Nesti C, Ballabio A, Borsani G (2000). "Expression of a novel human sialidase encoded by the NEU2 gene" . Glycobiology . 9 (12): 1313–1321. doi :10.1093/glycob/9.12.1313 PMID 10561456 . Hu H, Shioda T, Moriya C, Xin X, Hasan MK, Miyake K, Shimada T, Nagai Y (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface" . J. Virol . 70 (11): 7462–70. doi :10.1128/JVI.70.11.7462-7470.1996 . PMC 190813 PMID 8892864 . Miyagi T, Konno K, Emori Y, Kawasaki H, Suzuki K, Yasui A, Tsuik S (1994). "Molecular cloning and expression of cDNA encoding rat skeletal muscle cytosolic sialidase" . J. Biol. Chem . 268 (35): 26435–40. doi :10.1016/S0021-9258(19)74333-6 PMID 8253770 .
PDBe-KB provides an overview of all the structure information available in the PDB for Human Sialidase-2
PDB gallery
1snt : Structure of the human cytosolic sialidase Neu2
1so7 : Maltose-induced structure of the human cytolsolic sialidase Neu2
1vcu : Structure of the human cytosolic sialidase Neu2 in complex with the inhibitor DANA
2f0z : Crystal Structure of the Human Sialidase Neu2 in Complex with Zanamivir inhibitor
2f10 : Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor
2f11 : Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor
2f12 : Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor
2f13 : Crystal Structure of the Human Sialidase Neu2 in Complex with 2',3'- dihydroxypropyl ether mimetic Inhibitor
2f24 : Crystal Structure of the Human Sialidase Neu2 E111Q Mutant
2f25 : Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor
2f26 : Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant
2f27 : Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor
2f28 : Crystal Structure of the Human Sialidase Neu2 Q116E Mutant
2f29 : Crystal Structure of the Human Sialidase Neu2 Q116E Mutant in Complex with DANA Inhibitor
