Seraticin

Seraticin
Identifiers
CAS Number	1039756-04-1;
Properties
Chemical formula	C10H16N6O9
Molar mass	364.271 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Seraticin is an antibiotic discovered by scientists at Swansea University able to inhibit 12 different strains of methicillin-resistant Staphylococcus aureus (MRSA), as well as E. coli and C. difficile. The research was funded by the charity Action Medical Research, with support from the Rosetrees Trust. Seraticin was isolated as a compound of less than 500 Da molecular weight from the maggot secretions of the common green bottle fly (Lucilia sericata)^[1]^[2]^[3] It was patented in 2010 and has the molecular formula C
₁₀H
₁₆N
₆O
₉, but its chemical identity is unknown.^[4]

It is speculated that mechanism of action for seraticin is inhibition of septal formation and cell division.^[5]^: 162

References

^ "Multi-Tasking Maggots In Superbug Showdown". ScienceDaily. 11 August 2012. Retrieved 8 December 2012.
^ Bexfield A, Bond AE, Roberts EC, et al. (April 2008). "The antibacterial activity against MRSA strains and other bacteria of a <500 Da fraction from maggot excretions/secretions of Lucilia sericata (Diptera: Calliphoridae)". Microbes Infect. 10 (4): 325–33. doi:10.1016/j.micinf.2007.12.011. PMID 18400544.
^ Nigam, Yamni (2017-01-10). "Creepy, crawly maggots are actually a medical powerhouse". The Conversation. Retrieved 2023-12-04.
^ "(WO2011042684) Antimicrobial Composition and a Method of Controlling Contamination and Infection Using Said Composition". US Patent. October 1, 2010. Retrieved 8 December 2012.
^ Nigam, Yamni; Wilson, Michael R. (2022-07-18), "9. The Antimicrobial Activity of Medicinal Maggots", A Complete Guide to Maggot Therapy, Cambridge, UK: Open Book Publishers, pp. 153–174, doi:10.11647/obp.0300.09, ISBN 978-1-80064-728-2

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[1] "Multi-Tasking Maggots In Superbug Showdown". ScienceDaily. 11 August 2012. Retrieved 8 December 2012.

[2] Bexfield A, Bond AE, Roberts EC, et al. (April 2008). "The antibacterial activity against MRSA strains and other bacteria of a <500 Da fraction from maggot excretions/secretions of Lucilia sericata (Diptera: Calliphoridae)". Microbes Infect. 10 (4): 325–33. doi:10.1016/j.micinf.2007.12.011. PMID 18400544.

[3] Nigam, Yamni (2017-01-10). "Creepy, crawly maggots are actually a medical powerhouse". The Conversation. Retrieved 2023-12-04.

[patent-4] "(WO2011042684) Antimicrobial Composition and a Method of Controlling Contamination and Infection Using Said Composition". US Patent. October 1, 2010. Retrieved 8 December 2012.

[5] Nigam, Yamni; Wilson, Michael R. (2022-07-18), "9. The Antimicrobial Activity of Medicinal Maggots", A Complete Guide to Maggot Therapy, Cambridge, UK: Open Book Publishers, pp. 153–174, doi:10.11647/obp.0300.09, ISBN 978-1-80064-728-2

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