Scyllo-inosamine-4-phosphate amidinotransferase
| scyllo-inosamine-4-phosphate amidinotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.4.2 | ||||||||
| CAS no. | 52227-63-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a scyllo-inosamine-4-phosphate amidinotransferase (EC 2.1.4.2) is an enzyme that catalyzes the chemical reaction
- L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
Thus, the two substrates of this enzyme are L-arginine and 1-amino-1-deoxy-scyllo-inositol 4-phosphate, whereas its two products are L-ornithine and 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate.
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the amidinotransferases. The systematic name of this enzyme class is L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase. Other names in common use include L-arginine:inosamine-P-amidinotransferase, inosamine-P amidinotransferase, L-arginine:inosamine phosphate amidinotransferase, and inosamine-phosphate amidinotransferase. This enzyme participates in streptomycin biosynthesis.
Structural studies
[edit]As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1BWD.
References
[edit]- Walker MS, Walker JB (1966). "Enzymic studies on the biosynthesis of streptomycin, transamidation of inosamine and streptamine derivatives". J. Biol. Chem. 241 (6): 1262–1269. doi:10.1016/S0021-9258(18)96769-4. PMID 5935341.
