Sara Snogerup Linse
Sara Snogerup Linse | |
|---|---|
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| Alma mater | Lund University Stanford University |
| Scientific career | |
| Institutions | Lund University |
Sara Snogerup Linse (born 30 April 1962) is a Swedish Professor of Biochemistry at Lund University. Her research considers the molecular mechanisms of protein self-assembly in Alzheimer's disease. She serves as Chair of the Committee for the Nobel Prize in Chemistry. She was awarded the 2019 European Molecular Biology Organization Women in Science Award.
Early life and education
[edit]Linse grew up in the Oskarshamn Municipality.[1] Her parents are both botanists.[2] She was thirteen years old when she first learned about proteins, and her high school teachers told her that there were still mysteries in establishing their structure – function properties.[2] She studied chemical engineering at Lund University and Stanford University.[3] She graduated in 1985 and started a doctorate at Lund University in physical chemistry.[3] She then came across another challenge in biochemistry: the interaction of proteins with nanoparticles.[2]
Research and career
[edit]Linse was appointed to the faculty at Lund University in 1993, where she was promoted to Professor in 2004.[4] Her research considers the molecular basis of neurological and metabolic diseases.[3]
When proteins spontaneously aggregate they can form fibrous clumps known as amyloids. Amyloid-beta peptides are associated with several neurological diseases, including Alzheimer's and Parkinson's disease.[5] Linse has demonstrated that the process of nucleation and growth of amyloid-beta peptide occurs in two phases; first the amyloid fibrils form and then monomers nucleate on the surface.[2] This second nucleation event gives rise to most of the neuronal toxicity.[2] Linse was supported by the Knut and Alice Wallenberg Foundation to investigate the role of fat in protein self-assembly.[5] Fat molecules (lipids) are often present when aggregations are formed, but the majority of research considers how proteins attach to the cell membrane.[5]
Her research makes use of a variety of analytical tools to study protein amyloid formation.[6][7] In 2020 Linse and co-workers announced a mathematical model that could be used to describe the chemical reactions that are responsible for the fibroid aggregation associated with Alzheimer's disease.[8]
Awards and honours
[edit]Her awards and honours include:
- 2004 Elected to the Royal Swedish Academy of Sciences[3]
- 2007 National Academy of Sciences Cozzarelli Prize[9][10]
- 2011 International Union of Pure and Applied Chemistry Distinguished Woman in Chemistry prize[11]
- 2012 Joined the Nobel Prize in Chemistry Committee[3]
- 2014 KTH Royal Institute of Technology Great Prize[3]
- 2019 European Molecular Biology Organization Women in Science Award[12]
Selected publications
[edit]Her publications include:
- Linse, Sara (2007-02-13). "Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles". Proceedings of the National Academy of Sciences. 104 (7): 2050–2055. doi:10.1073/pnas.0608582104. PMC 1892985. PMID 17267609.
- Linse, Sara (2007-05-22). "Nucleation of protein fibrillation by nanoparticles". Proceedings of the National Academy of Sciences. 104 (21): 8691–8696. Bibcode:2007PNAS..104.8691L. doi:10.1073/pnas.0701250104. PMC 1866183. PMID 17485668.
- Linse, Sara (2007-10-31). "The nanoparticle–protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century". Proceedings of the National Academy of Sciences. 134: 167–174. doi:10.1016/j.cis.2007.04.021. PMID 17574200.
Linse publishes children's books with her partner Kyrre Thalberg.[3][13] These have included Draksommar,[14] Kjetil och Jostein,[15] Höst i Drakbergen,[16] Prins Pralin åker buss,[17] and Karnevalen i Brind.[18] She is also 2018 World Masters Orienteering Champion.[19]
References
[edit]- ^ "Välorienterad professor på språng". Sydsvenskan (in Swedish). 29 April 2012. Retrieved 2020-02-15.
- ^ a b c d e Network, FEBS (2019-03-03). "Sara Linse: "I really love working in the lab"". FEBS Network. Retrieved 2020-02-15.
- ^ a b c d e f g "The KTH Great Prize 2014 awarded to Sara Snogerup Linse". KTH. Retrieved 2020-02-15.
- ^ "Sara Snogerup Linse | Center for Molecular Protein Science, CMPS". www.cmps.lu.se. Retrieved 2020-02-15.
- ^ a b c "The role of fats in protein clumps". Knut and Alice Wallenberg Foundation. Retrieved 2020-02-15.
- ^ "Professor Sara Linse presents new data on protein interactions in Alzheimer's disease using the Fluidity One-W at FEBS 2019". www.fluidic.com. Retrieved 2020-02-15.
- ^ "Professor Sara Linse presents new data on protein interactions in Alzheimer's disease using the Fluidity One-W at FEBS 2019 | Cambridge Network". www.cambridgenetwork.co.uk. Retrieved 2020-02-15.
- ^ "New mathematical model for amyloid formation: Equations describe chemical reactions responsible for the formation of protein aggregates associated with illnesses like Alzheimer's disease". ScienceDaily. Retrieved 2020-02-15.
- ^ "The Cozzarelli Prize: 2019 Call for Nominations | PNAS". www.pnas.org. Retrieved 2020-02-15.
- ^ "PNAS Announces 2007 Cozzarelli Prize Recipients". www8.nationalacademies.org. Retrieved 2020-02-15.
- ^ "IUPAC Distinguished Women in Chemistry". IUPAC 100. Retrieved 2020-02-15.
- ^ "FEBS | Sara Linse receives the 2019 FEBS | EMBO Women in Science Award | News". www.febs.org. Retrieved 2020-02-15.
- ^ EMBO (18 February 2019). "I really love working in the lab". EMBO. Retrieved 2020-02-15.
- ^ Thalberg, Kyrre; Snogerup Linse, Sara (2012). Draksommar (in Swedish). Mjölby: Atremi. ISBN 978-91-7527-021-0. OCLC 939732854.
- ^ Thalberg, Kyrre; Snogerup Linse, Sara (2013). Kjetil och Jostein (in Swedish). Mjölby: Atremi. ISBN 978-91-7527-057-9. OCLC 940620266.
- ^ Thalberg, Kyrre; Snogerup Linse, Sara (2014). Höst i Drakbergen (in Swedish). Mjölby: Atremi. ISBN 978-91-7527-095-1. OCLC 941226080.
- ^ Thalberg, Kyrre; Snogerup Linse, Sara (2013). Prins Pralin åker buss (in Swedish). Mjölby: Atremi. ISBN 978-91-7527-030-2. OCLC 940304639.
- ^ Snogerup Linse, Sara; Thalberg, Kyrre; Snogerup, Sara; Thalberg, Kyrre; Snogerup, Sara; Thalberg, Kyrre (2019). Karnevalen i Brind (in Swedish). ISBN 978-91-7527-255-9. OCLC 1111658695.
- ^ "IOF Eventor - Sara Snogerup Linse". eventor.orienteering.org. Retrieved 2020-02-16.
