STRN

STRN
Identifiers
Aliases	STRN, SG2NA, PPP2R6A, striatin, STRN1
External IDs	OMIM: 614765; MGI: 1333757; HomoloGene: 2380; GeneCards: STRN; OMA:STRN - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	36,966,536 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	79,044,625 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; amniotic fluid; ; corpus callosum; ; gingival epithelium; ; Achilles tendon; ; oral cavity; ; inferior ganglion of vagus nerve; ; germinal epithelium; ; subthalamic nucleus; ; epithelium of colon;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; dorsal striatum; ; olfactory tubercle; ; nucleus accumbens; ; cumulus cell; ; substantia nigra; ; superior frontal gyrus; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 2A binding; estrogen receptor binding; protein binding; calmodulin binding; armadillo repeat domain binding; protein-containing complex binding;
Cellular component	cytoplasm; soma; postsynaptic membrane; dendritic spine; protein phosphatase type 2A complex; cell projection; membrane; postsynaptic density; bicellular tight junction; dendrite; FAR/SIN/STRIPAK complex;
Biological process	dendrite development; Wnt signaling pathway; locomotory behavior; negative regulation of cell population proliferation; bicellular tight junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	6801
	268980
	ENSG00000115808
	ENSMUSG00000024077
	O43815
	O55106
	NM_003162
	NM_011500
	NP_003153
	NP_035630
	Wikidata
View/Edit Human	View/Edit Mouse

Striatin is a protein that in humans is encoded by the STRN gene.^[5]^[6]^[7]

Interactions

STRN has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115808 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024077 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Moqrich A, Mattei MG, Bartoli M, Rakitina T, Baillat G, Monneron A, Castets F (Jul 1998). "Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain". Genomics. 51 (1): 136–9. doi:10.1006/geno.1998.5342. PMID 9693043.
^ Castets F, Bartoli M, Barnier JV, Baillat G, Salin P, Moqrich A, Bourgeois JP, Denizot F, Rougon G, Calothy G, Monneron A (Aug 1996). "A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons". The Journal of Cell Biology. 134 (4): 1051–62. doi:10.1083/jcb.134.4.1051. PMC 2120968. PMID 8769426.
^ "Entrez Gene: STRN striatin, calmodulin binding protein".
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Moreno CS, Park S, Nelson K, Ashby D, Hubalek F, Lane WS, Pallas DC (Feb 2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". The Journal of Biological Chemistry. 275 (8): 5257–63. doi:10.1074/jbc.275.8.5257. PMC 3505218. PMID 10681496.
Gaillard S, Bartoli M, Castets F, Monneron A (Nov 2001). "Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1". FEBS Letters. 508 (1): 49–52. doi:10.1016/S0014-5793(01)03020-4. PMID 11707266. S2CID 7887096.
Huang Y, Tang R, Dai J, Gu S, Zhao W, Cheng C, Xu M, Zhou Z, Ying K, Xi Y, Mao Y (2002). "A novel human hydroxysteroid dehydrogenase like 1 gene (HSDL1) is highly expressed in reproductive tissues". Molecular Biology Reports. 28 (4): 185–91. doi:10.1023/A:1015726217890. PMID 12153137. S2CID 9167130.
Hwang J, Pallas DC (February 2014). "STRIPAK complexes: structure, biological function, and involvement in human diseases". The International Journal of Biochemistry & Cell Biology. 47: 118–48. doi:10.1016/j.biocel.2013.11.021. PMC 3927685. PMID 24333164.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH (Dec 2004). "Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha". Proceedings of the National Academy of Sciences of the United States of America. 101 (49): 17126–31. Bibcode:2004PNAS..10117126L. doi:10.1073/pnas.0407492101. PMC 534607. PMID 15569929.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115808 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024077 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9693043-5] Moqrich A, Mattei MG, Bartoli M, Rakitina T, Baillat G, Monneron A, Castets F (Jul 1998). "Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain". Genomics. 51 (1): 136–9. doi:10.1006/geno.1998.5342. PMID 9693043.

[pmid8769426-6] Castets F, Bartoli M, Barnier JV, Baillat G, Salin P, Moqrich A, Bourgeois JP, Denizot F, Rougon G, Calothy G, Monneron A (Aug 1996). "A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons". The Journal of Cell Biology. 134 (4): 1051–62. doi:10.1083/jcb.134.4.1051. PMC 2120968. PMID 8769426.

[entrez-7] "Entrez Gene: STRN striatin, calmodulin binding protein".

[pmid18782753-8] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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Interactions

References

Further reading