ST8SIA6

ST8SIA6
Identifiers
Aliases	ST8SIA6, SIA8F, SIAT8F, ST8SIA-VI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6, ST8SiaVI, SIAT8-F
External IDs	OMIM: 610139; MGI: 2386797; HomoloGene: 17112; GeneCards: ST8SIA6; OMA:ST8SIA6 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	17,454,595 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	13,798,875 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; substantia nigra; ; apex of heart; ; left ventricle; ; right auricle; ; epithelium of colon; ; lung; ; thymus; ; white blood cell;
	Top expressed in
	conjunctival fornix; ; transitional epithelium of urinary bladder; ; substantia nigra; ; epithelium of stomach; ; hair follicle; ; cornea; ; lateral septal nucleus; ; lacrimal gland; ; ciliary body; ; lumbar subsegment of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; sialyltransferase activity; glycosyltransferase activity; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	glycolipid biosynthetic process; sialylation; protein glycosylation; protein O-linked glycosylation; glycoprotein metabolic process; oligosaccharide metabolic process; ganglioside biosynthetic process; carbohydrate biosynthetic process; blastocyst hatching;
	Sources:Amigo / QuickGO
Orthologs
	338596
	241230
	ENSG00000148488
	ENSMUSG00000003418
	P61647
	Q8K4T1
	NM_001004470; NM_001345961
	NM_145838
	NP_001004470; NP_001332890
	NP_665837
	Wikidata
View/Edit Human	View/Edit Mouse

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene. ^[5]

Function

Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148488 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003418 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6". Retrieved 2017-02-02.

Avril T, North SJ, Haslam SM, Willison HJ, Crocker PR (2006). "Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression". J. Leukoc. Biol. 80 (4): 787–96. doi:10.1189/jlb.1005559. PMID 16857734. S2CID 7578193.
Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37 (2): 210–270. doi:10.1002/med.21407. PMID 27678392. S2CID 26280291.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148488 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003418 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6". Retrieved 2017-02-02.

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Function

References

Further reading