ST6GALNAC6

ST6GALNAC6
Identifiers
Aliases	ST6GALNAC6, SIAT7-F, SIAT7F, ST6GALNACVI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
External IDs	OMIM: 610135; MGI: 1355316; HomoloGene: 8390; GeneCards: ST6GALNAC6; OMA:ST6GALNAC6 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	127,905,408 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,510,818 bp
RNA expression pattern
	Top expressed in
	amygdala; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; anterior cingulate cortex; ; right frontal lobe; ; hippocampus proper; ; rectum; ; right coronary artery; ; dorsolateral prefrontal cortex;
	Top expressed in
	left colon; ; superior frontal gyrus; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; cerebellar cortex; ; muscle of thigh; ; right ventricle; ; olfactory tubercle; ; ciliary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; sialyltransferase activity; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; plasma membrane; Golgi membrane; cytoplasm;
Biological process	cell-cell recognition; glycoprotein metabolic process; glycosphingolipid metabolic process; protein glycosylation; glycosylceramide metabolic process; oligosaccharide metabolic process; sialylation; protein N-linked glycosylation via asparagine; ganglioside biosynthetic process; oligosaccharide biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	30815
	50935
	ENSG00000160408
	ENSMUSG00000026811
	Q969X2
	Q9JM95
NM_001286999; NM_001287000; NM_001287001; NM_001287002; NM_001287003;
	NM_013443; NM_001388489
NM_001025310; NM_001025311; NM_001289547; NM_001289548; NM_001289549;
	NM_016973
NP_001273928; NP_001273929; NP_001273930; NP_001273931; NP_001273932;
	NP_038471
NP_001020481; NP_001020482; NP_001276476; NP_001276477; NP_001276478;
	NP_058669
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160408 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026811 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K (Jun 2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides". J Biol Chem. 278 (25): 22787–94. doi:10.1074/jbc.M211034200. PMID 12668675.
^ "Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6".

Senda M, Ito A, Tsuchida A, et al. (2007). "Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers". Biochem. J. 402 (3): 459–70. doi:10.1042/BJ20061118. PMC 1863573. PMID 17123352.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Harduin-Lepers A, Mollicone R, Delannoy P, Oriol R (2005). "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach". Glycobiology. 15 (8): 805–17. doi:10.1093/glycob/cwi063. PMID 15843597.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Okajima T, Chen HH, Ito H, et al. (2000). "Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene". J. Biol. Chem. 275 (10): 6717–23. doi:10.1074/jbc.275.10.6717. PMID 10702226.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160408 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026811 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12668675-5] Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K (Jun 2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides". J Biol Chem. 278 (25): 22787–94. doi:10.1074/jbc.M211034200. PMID 12668675.

[entrez-6] "Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6".

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References

Further reading