The gene and intron-exon structure were first predicted through analysis of the complete sequence of human chromosome 7, its initial designation being C7orf45.[6][7] Human mRNA transcripts were identified through two large scale cDNA cloning efforts, an American effort run out of the Dana-Farber Cancer Institute and Harvard Medical School, and full-length long Japan effort. Later assigned the official symbol SSMEM1, the gene is located on the long arm of chromosome 7 (7q32.2) on the sense strand in humans.[8] The human mRNA transcript is 1171 bp long with three exons.[9]
In humans, serine-rich single pass membrane protein 1 is 244 amino acids long with a transmembrane domain region spanning amino acids 35-55.[5] This protein has a domain of unknown function (DUF4636) that spans almost all of the protein (amino acids 1-243).[5] DUF4636 belongs to pfam15468 which is a part of the superfamily cl21285 that is found in eukaryotes and typically 196 to 244 amino acids long.[5] The human protein has a molecular weight of 28036 Da and an isoelectric point of 7.64.[5][14]
